GDI1 - Rab GDP dissociation inhibitor alpha - human protein (Function)
 
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GDI1 »  Rab GDP dissociation inhibitor alpha  (Rab GDI alpha)
 
Protein also known as:  Guanosine diphosphate dissociation inhibitor 1 (GDI-1).
Gene name:  GDI1
Family name: Rab GDI
Entry whose protein(s) existence is based on evidence at protein level
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1 42 1
GENE REF ISO

Function

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Overview 
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.  
  • CuratedUniProtKB
GO molecular function 
GDP-dissociation inhibitor activitydefinition[GO:0005092]  
1
  • TASPINC
GTPase activator activitydefinition[GO:0005096]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Rab GDP-dissociation inhibitor activitydefinition[GO:0005093]  
  • ISSOrtholog Curator
Rab GTPase bindingdefinition[GO:0017137] silver  
  • IEAOrtholog Compara
GO biological process 
Negative regulation of axonogenesisdefinition[GO:0050771]  
  • ISSOrtholog Curator
Negative regulation of protein targeting to membranedefinition[GO:0090315]  
1
  • IMPUniProtKB
Protein transportdefinition[GO:0015031] silver  
  • IEAInterPro 2 GO
Rab protein signal transductiondefinition[GO:0032482]  
  • ISSOrtholog Curator
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • TASGOC
  • ISSOrtholog Curator
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
GTPase activation  definition   [KW-0343]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GDI1
GenomeRNAi: 2664
PRO: PR:P31150