MAPK4 - Mitogen-activated protein kinase 4 - human protein (Function)
 
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MAPK4 »  Mitogen-activated protein kinase 4   [ EC 2.7.11.24 ]  (MAPK 4)
 
Protein also known as:  Extracellular signal-regulated kinase 4 (ERK-4).
Gene name:  MAPK4
Entry whose protein(s) existence is based on evidence at protein level
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1 29 1
GENE REF ISO

Function

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Overview 
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
MAP kinase activitydefinition[GO:0004707]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
Protein homodimerization activitydefinition[GO:0042803]  
  • ISSOrtholog Curator
Protein kinase bindingdefinition[GO:0019901]  
  • ISSOrtholog Curator
GO biological process 
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
MAPK cascadedefinition[GO:0000165]  
1
  • TASGOC
  • IEAInterPro 2 GO
  • IEAEC 2 GO
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.24: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by phosphorylation at Ser-186.  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAPK4
GenomeRNAi: 5596
PRO: PR:P31152
Chemistry
GuidetoPHARMACOLOGY: 2091