SLC5A2 - Sodium/glucose cotransporter 2 - human protein (Function)
 
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SLC5A2 »  Sodium/glucose cotransporter 2  (Na(+)/glucose cotransporter 2)
 
Protein also known as:  Low affinity sodium-glucose cotransporter.
Gene name:  SLC5A2
Entry whose protein(s) existence is based on evidence at protein level
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1 31 1
GENE REF ISO

Function

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Overview 
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.  
  • CuratedUniProtKB
Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the solute:sodium symporter (sss) family  2.A.21.3.16  
GO molecular function 
Low-affinity glucose:sodium symporter activitydefinition[GO:0005362]  
1
  • TASPINC
GO biological process 
Carbohydrate metabolic processdefinition[GO:0005975]  
1
  • TASPINC
Glucose transportdefinition[GO:0015758]  
1
  • TASGOC
Sodium ion transportdefinition[GO:0006814]  
  • IEAUniProtKB KW
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
Hexose transport  REACT_9441  
Inositol transporters  REACT_19188  
Na+-dependent glucose transporters  REACT_19165  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Sugar transport  definition   [KW-0762]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SLC5A2
GenomeRNAi: 6524
PRO: PR:P31639
Chemistry
GuidetoPHARMACOLOGY: 916