SLC6A4 - Sodium-dependent serotonin transporter - human protein (Function)
 
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SLC6A4 »  Sodium-dependent serotonin transporter
 
Protein also known as:  Solute carrier family 6 member 4.
Gene name:  SLC6A4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 953 2
GENE REF ISO

Function

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Overview 
Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter:sodium symporter (nss) family  2.A.22.1.1  
GO molecular function 
Actin filament bindingdefinition[GO:0051015]  
1
  • Ortholog Curator
Cocaine bindingdefinition[GO:0019811] silver  
1
  • Ortholog Compara
Monoamine transmembrane transporter activitydefinition[GO:0008504]  
1
  • MGI
Myosin bindingdefinition[GO:0017022] silver  
1
  • Ortholog Compara
Nitric-oxide synthase bindingdefinition[GO:0050998] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Rab GTPase bindingdefinition[GO:0017137]  
1
  • UniProtKB
Serotonin transmembrane transporter activitydefinition[GO:0015222]  
2
  • UniProtKB
Serotonin:sodium symporter activitydefinition[GO:0005335]  
2
  • UniProtKB
Syntaxin-1 bindingdefinition[GO:0017075] silver  
1
  • Ortholog Compara
GO biological process 
Brain morphogenesisdefinition[GO:0048854]  
1
  • Ortholog Curator
Cellular response to cGMPdefinition[GO:0071321] silver  
1
  • Ortholog Compara
Cellular response to retinoic aciddefinition[GO:0071300] silver  
1
  • Ortholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
1
  • Ortholog Compara
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
Monoamine transportdefinition[GO:0015844]  
1
  • MGI
Negative regulation of cerebellar granule cell precursor proliferationdefinition[GO:0021941] silver  
1
  • Ortholog Compara
Negative regulation of neuron differentiationdefinition[GO:0045665] silver  
1
  • Ortholog Compara
Negative regulation of organ growthdefinition[GO:0046621]  
1
  • Ortholog Curator
Negative regulation of synaptic transmission, dopaminergicdefinition[GO:0032227] silver  
1
  • Ortholog Compara
Positive regulation of cell cycledefinition[GO:0045787] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628] silver  
1
  • Ortholog Compara
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • Ortholog Compara
Protein oligomerizationdefinition[GO:0051259]  
1
  • Ortholog Curator
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to estradioldefinition[GO:0032355] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
Response to toxic substancedefinition[GO:0009636]  
1
  • UniProtKB
Serotonin transportdefinition[GO:0006837]  
1
  • UniProtKB
Serotonin uptakedefinition[GO:0051610]  
6
  • UniProtKB
  • CACAO
Social behaviordefinition[GO:0035176]  
1
  • Ortholog Curator
Sperm ejaculationdefinition[GO:0042713] silver  
1
  • Ortholog Compara
Thalamus developmentdefinition[GO:0021794]  
1
  • UniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • UniProtKB KW
Vasoconstrictiondefinition[GO:0042310] silver  
1
  • Ortholog Compara
Note 
This protein is the target of psychomotor stimulants such as amphetamines or cocaine.  
1
  • UniProtKB
 

Keywords

Biological process 
Neurotransmitter transport  definition   [KW-0532]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Serotonin_transporter
GenomeRNAi: 6532
PRO: PR:P31645
Chemistry
GuidetoPHARMACOLOGY: 928