ATIC - Bifunctional purine biosynthesis protein PURH - human protein (Function)
 
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ATIC »  Bifunctional purine biosynthesis protein PURH
 
Gene name:  ATIC
Family name: PurH
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.  
1
  • CuratedUniProtKB
GO molecular function 
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IPIUniProtKB
GO biological process 
'de novo' IMP biosynthetic processdefinition[GO:0006189]  
  • IEAUniPathway
Brainstem developmentdefinition[GO:0003360] silver  
  • IEAOrtholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
  • IEAOrtholog Compara
Cerebral cortex developmentdefinition[GO:0021987] silver  
  • IEAOrtholog Compara
Dihydrofolate metabolic processdefinition[GO:0046452] silver  
  • IEAOrtholog Compara
Nucleobase-containing compound metabolic processdefinition[GO:0006139]  
1
  • TASPINC
Nucleoside metabolic processdefinition[GO:0009116] silver  
  • IEAOrtholog Compara
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Response to inorganic substancedefinition[GO:0010035] silver  
  • IEAOrtholog Compara
Tetrahydrofolate biosynthetic processdefinition[GO:0046654] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.1.2.3: 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.  
  • CuratedUniProtKB
EC 3.5.4.10: IMP + H(2)O 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+471  
One carbon pool by folate  hsa00670+471  
Purine metabolism  hsa00230+471  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Hydrolase  definition   [KW-0378]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P31939
Other
GeneWiki: Inosine_monophosphate_synthase
GenomeRNAi: 471
PRO: PR:P31939