CASP14 - Caspase-14 - human protein (Function)
 
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CASP14 »  Caspase-14   [ EC 3.4.22.- ]  (CASP-14)
 
Cleaved into:  Caspase-14 subunit p10; Caspase-14 subunit p19.
Gene name:  CASP14
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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1 42 1
GENE REF ISO

Function

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Overview 
Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IBARefGenome
GO biological process 
Cornificationdefinition[GO:0070268]  
1
  • TASUniProtKB
Epidermis developmentdefinition[GO:0008544]  
1
  • TASPINC
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192] silver  
  • IBARefGenome
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IBARefGenome
Keratinizationdefinition[GO:0031424]  
1
  • TASUniProtKB
Enzymatic activity 
 
More information is available from:
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Caspase_14
GenomeRNAi: 23581
PRO: PR:P31944