CASP14 - Caspase-14 - human protein (Function)
 
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CASP14 »  Caspase-14   [ EC 3.4.22.- ]  (CASP-14)
 
Cleaved into:  Caspase-14 subunit p10, mature form; Caspase-14 subunit p17, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form.
Gene name:  CASP14
Family name: Peptidase C14A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed16854378, PubMed19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed24743736).  
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  • UniProtKB
GO molecular function 
Cysteine-type endopeptidase activitydefinition[GO:0004197]  
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  • PINC
Cysteine-type endopeptidase activity involved in apoptotic signaling pathwaydefinition[GO:0097199]  
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  • RefGenome
Protein bindingdefinition[GO:0005515]  
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  • IntAct
GO biological process 
Activation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0006919]  
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  • RefGenome
Cornificationdefinition[GO:0070268]  
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  • UniProtKB
Epidermis developmentdefinition[GO:0008544]  
1
  • PINC
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192]  
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  • RefGenome
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630]  
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  • RefGenome
Keratinizationdefinition[GO:0031424]  
1
  • UniProtKB
Enzymatic activity 
It is regulated in the following manner
Inhibited by caspase-1 inhibitor YVAD-FMK and the pan-caspase inhibitor VAD-FMK.  
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  • UniProtKB
 
More information is available from:
Note 
Expressed in bacteria requires high concentrations of kosmotropic salts to be activated (PubMed15301553). The mature and the intermediate form differ in activity towards synthetic caspase substrates: the p17/p10 mature form but not the p20/p8 intermediate form is active on WEHD-MCA; p20/p8 is active on a number of other caspase substrates without any marked preference (VEID-AFC, DEVD-AFC, LEVD-AFC and LEHD-AFC) (PubMed22825846).  
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  • UniProtKB
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Caspase_14
GenomeRNAi: 23581
PRO: PR:P31944