YWHAB - 14-3-3 protein beta/alpha - human protein (Function)
 
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YWHAB »  14-3-3 protein beta/alpha
 
Protein also known as:  Protein kinase C inhibitor protein 1 (KCIP-1). Cleaved into:  14-3-3 protein beta/alpha, N-terminally processed.
Gene name:  YWHAB
Family name: 14-3-3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 132 2
GENE REF ISO

Function

 show evidences
Overview 
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.  
2
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • IPIBHF-UCL
Phosphoprotein bindingdefinition[GO:0051219]  
1
  • IPIBHF-UCL
Phosphoserine bindingdefinition[GO:0050815]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
52
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
  • IEAOrtholog Compara
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Transcription corepressor activitydefinition[GO:0003714] silver  
  • IEAOrtholog Compara
GO biological process 
Cytoplasmic sequestering of proteindefinition[GO:0051220]  
1
  • IDABHF-UCL
Negative regulation of protein dephosphorylationdefinition[GO:0035308]  
1
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
  • IEAOrtholog Compara
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDABHF-UCL
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Protein targetingdefinition[GO:0006605] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+7529  
Neurotrophin signaling pathway  hsa04722+7529  
Oocyte meiosis  hsa04114+7529  
According to Reactome, this protein belongs to the following pathways:
Apoptosis  REACT_578  
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Gene Expression  REACT_71  
Immune System  REACT_6900  
Membrane Trafficking  REACT_11123  
Metabolism of RNA  REACT_21257  
Signal Transduction  REACT_111102  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: YWHAB
GenomeRNAi: 7529
PRO: PR:P31946