YWHAB - 14-3-3 protein beta/alpha - human protein (Function)
 
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YWHAB »  14-3-3 protein beta/alpha
 
Protein also known as:  Protein kinase C inhibitor protein 1 (KCIP-1). Cleaved into:  14-3-3 protein beta/alpha, N-terminally processed.
Gene name:  YWHAB
Family name: 14-3-3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.  
3
  • UniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • BHF-UCL
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • BHF-UCL
Phosphoprotein bindingdefinition[GO:0051219]  
1
  • BHF-UCL
Phosphoserine bindingdefinition[GO:0050815]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
54
  • IntAct
  • BHF-UCL
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022] silver  
1
  • Ortholog Compara
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
Transcription corepressor activitydefinition[GO:0003714] silver  
1
  • Ortholog Compara
GO biological process 
Cytoplasmic sequestering of proteindefinition[GO:0051220]  
1
  • BHF-UCL
Negative regulation of protein dephosphorylationdefinition[GO:0035308]  
1
  • BHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892] silver  
1
  • Ortholog Compara
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • BHF-UCL
Protein heterooligomerizationdefinition[GO:0051291] silver  
1
  • Ortholog Compara
Protein targetingdefinition[GO:0006605] silver  
1
  • Ortholog Compara
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+7529  
Neurotrophin signaling pathway  hsa04722+7529  
Oocyte meiosis  hsa04114+7529  
According to Reactome, this protein belongs to the following pathways:
Activation of BAD and translocation to mitochondria  R-HSA-111447  
ARMS-mediated activation  R-HSA-170984  
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA  R-HSA-450385  
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex  R-HSA-75035  
Frs2-mediated activation  R-HSA-170968  
MAP2K and MAPK activation  R-HSA-5674135  
mTOR signalling  R-HSA-165159  
mTORC1-mediated signalling  R-HSA-166208  
Negative regulation of MAPK pathway  R-HSA-5675221  
RAF activation  R-HSA-5673000  
Rap1 signalling  R-HSA-392517  
RHO GTPases activate PKNs  R-HSA-5625740  
Signaling by Hippo  R-HSA-2028269  
TP53 Regulates Metabolic Genes  R-HSA-5628897  
Translocation of GLUT4 to the plasma membrane  R-HSA-1445148  
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA  R-HSA-450513  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: YWHAB
GenomeRNAi: 7529
PRO: PR:P31946