L1CAM - Neural cell adhesion molecule L1 - human protein (Function)
 
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Protein
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L1CAM »  Neural cell adhesion molecule L1  (NCAM-L1)
 
Protein also known as:  CD antigen CD171.
Gene name:  L1CAM
Entry whose protein(s) existence is based on evidence at protein level
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1 186 3
GENE REF ISO

Function

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Overview 
Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.  
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Integrin bindingdefinition[GO:0005178] silver  
  • IEAOrtholog Compara
Protein self-associationdefinition[GO:0043621] silver  
  • IEAOrtholog Compara
Sialic acid bindingdefinition[GO:0033691] silver  
  • IEAOrtholog Compara
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • NASPINC
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
  • IEAOrtholog Compara
Cell-cell adhesion mediated by integrindefinition[GO:0033631] silver  
  • IEAOrtholog Compara
Chemotaxisdefinition[GO:0006935]  
1
  • TASBHF-UCL
Heterophilic cell-cell adhesiondefinition[GO:0007157] silver  
  • IEAOrtholog Compara
Homophilic cell adhesiondefinition[GO:0007156] silver  
  • IEAOrtholog Compara
Homotypic cell-cell adhesiondefinition[GO:0034109] silver  
  • IEAOrtholog Compara
Leukocyte cell-cell adhesiondefinition[GO:0007159] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Positive regulation of calcium-mediated signalingdefinition[GO:0050850] silver  
  • IEAOrtholog Compara
Positive regulation of cell-cell adhesiondefinition[GO:0022409] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+3897  
Cell adhesion molecules (CAMs)  hsa04514+3897  
According to Reactome, this protein belongs to the following pathways:
Basigin interactions  REACT_12560  
Interaction between L1 and Ankyrins  REACT_22266  
L1CAM interactions  REACT_22205  
Recycling pathway of L1  REACT_22365  
Signal transduction by L1  REACT_22272  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: L1_(protein)
GenomeRNAi: 3897
PRO: PR:P32004