CCKAR - Cholecystokinin receptor type A - human protein (Function)
 
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CCKAR »  Cholecystokinin receptor type A  (CCK-AR)
 
Protein also known as:  Cholecystokinin-1 receptor (CCK1-R).
Gene name:  CCKAR
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.  
  • CuratedUniProtKB
GO molecular function 
Cholecystokinin receptor activitydefinition[GO:0004951] silver  
  • IEAInterPro 2 GO
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
Cholecystokinin signaling pathwaydefinition[GO:0038188]  
1
  • TASGOC
Digestiondefinition[GO:0007586]  
1
  • TASPINC
Feeding behaviordefinition[GO:0007631]  
1
  • TASPINC
Forebrain developmentdefinition[GO:0030900] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • TASPINC
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Response to nutrientdefinition[GO:0007584]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+886  
Neuroactive ligand-receptor interaction  hsa04080+886  
Pancreatic secretion  hsa04972+886  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cholecystokinin_A_receptor
GenomeRNAi: 886
PRO: PR:P32238
Chemistry
GuidetoPHARMACOLOGY: 76