CCKBR - Gastrin/cholecystokinin type B receptor - human protein (Function)
 
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CCKBR »  Gastrin/cholecystokinin type B receptor
 
Gene name:  CCKBR
Entry whose protein(s) existence is based on evidence at protein level
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1 99 3
GENE REF ISO

Function

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Overview 
Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.  
6
  • CuratedUniProtKB
Isoform  Iso 2   Is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.  
6
  • CuratedUniProtKB
GO molecular function 
1-phosphatidylinositol-3-kinase regulator activitydefinition[GO:0046935]  
1
  • TASPINC
Cholecystokinin receptor activitydefinition[GO:0004951]  
1
  • TASPINC
Gastrin receptor activitydefinition[GO:0015054]  
1
  • IDAUniProtKB
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Type B gastrin/cholecystokinin receptor bindingdefinition[GO:0031741]  
2
  • IDANTNU_SB
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • NASUniProtKB
Cholecystokinin signaling pathwaydefinition[GO:0038188]  
1
  • TASGOC
Digestiondefinition[GO:0007586]  
1
  • TASPINC
Digestive tract developmentdefinition[GO:0048565] silver  
  • IEAOrtholog Compara
Feeding behaviordefinition[GO:0007631]  
1
  • TASPINC
Gastric acid secretiondefinition[GO:0001696] silver  
  • IEAOrtholog Compara
Gland developmentdefinition[GO:0048732] silver  
  • IEAOrtholog Compara
Metabolic processdefinition[GO:0008152]  
1
  • TASGOC
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • TASPINC
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IDAUniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
Regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043551]  
1
  • TASGOC
Sensory perceptiondefinition[GO:0007600]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+887  
Gastric acid secretion  hsa04971+887  
Neuroactive ligand-receptor interaction  hsa04080+887  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Gastrin-CREB signalling pathway via PKC and MAPK  REACT_120966  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cholecystokinin_B_receptor
GenomeRNAi: 887
PRO: PR:P32239
Chemistry
GuidetoPHARMACOLOGY: 77