OTX2 - Homeobox protein OTX2 - human protein (Function)
 
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OTX2 »  Homeobox protein OTX2
 
Protein also known as:  Orthodenticle homolog 2.
Gene name:  OTX2
Family name: Paired homeobox » Bicoid
Entry whose protein(s) existence is based on evidence at protein level
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1 57 2
GENE REF ISO

Function

 show evidences
Overview 
Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.  
  • CuratedUniProtKB
GO molecular function 
Eukaryotic initiation factor 4E bindingdefinition[GO:0008190]  
1
  • TASUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDANTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
2
  • IDAUniProtKB
  • IDANTNU_SB
GO biological process 
Axon guidancedefinition[GO:0007411]  
1
  • IDAUniProtKB
Cell fate specificationdefinition[GO:0001708] silver  
  • IEAOrtholog Compara
Diencephalon morphogenesisdefinition[GO:0048852] silver  
  • IEAOrtholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953] silver  
  • IEAOrtholog Compara
Endoderm developmentdefinition[GO:0007492] silver  
  • IEAOrtholog Compara
Eye photoreceptor cell fate commitmentdefinition[GO:0042706] silver  
  • IEAOrtholog Compara
Forebrain developmentdefinition[GO:0030900]  
1
  • TASUniProtKB
Inner ear morphogenesisdefinition[GO:0042472] silver  
  • IEAOrtholog Compara
Metencephalon developmentdefinition[GO:0022037] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901]  
1
  • TASUniProtKB
Positive regulation of embryonic developmentdefinition[GO:0040019]  
  • ISSOrtholog Curator
Positive regulation of gastrulationdefinition[GO:2000543]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAUniProtKB
  • IDANTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Primitive streak formationdefinition[GO:0090009]  
  • ISSOrtholog Curator
Protein complex assemblydefinition[GO:0006461]  
1
  • IDAUniProtKB
Regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040036]  
1
  • TASUniProtKB
Regulation of smoothened signaling pathwaydefinition[GO:0008589]  
1
  • TASUniProtKB
Somite rostral/caudal axis specificationdefinition[GO:0032525] silver  
  • IEAOrtholog Compara
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Orthodenticle_homeobox_2
GenomeRNAi: 5015
PRO: PR:P32243