CCR1 - C-C chemokine receptor type 1 - human protein (Function)
 
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Protein
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CCR1 »  C-C chemokine receptor type 1  (CCR1)
 
Protein also known as:  Macrophage inflammatory protein 1-alpha receptor (MIP-1alpha-R); CD antigen CD191.
Gene name:  CCR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 77 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.  
  • CuratedUniProtKB
GO molecular function 
C-C chemokine bindingdefinition[GO:0019957]  
4
  • IPIUniProtKB
C-C chemokine receptor activitydefinition[GO:0016493]  
1
  • IDAUniProtKB
Chemokine (C-C motif) ligand 5 bindingdefinition[GO:0071791]  
4
  • IPIUniProtKB
Chemokine (C-C motif) ligand 7 bindingdefinition[GO:0035717]  
2
  • IPIUniProtKB
Chemokine receptor activitydefinition[GO:0004950]  
1
  • IDAUniProtKB
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Calcium ion transportdefinition[GO:0006816]  
1
  • IDAUniProtKB
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • IDAUniProtKB
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • IDAUniProtKB
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
1
  • IDAUniProtKB
Chemotaxisdefinition[GO:0006935]  
1
  • NASUniProtKB
Cytokine-mediated signaling pathwaydefinition[GO:0019221]  
1
  • NASUniProtKB
Dendritic cell chemotaxisdefinition[GO:0002407]  
1
  • TASBHF-UCL
Exocytosisdefinition[GO:0006887]  
1
  • IDAUniProtKB
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Immune responsedefinition[GO:0006955]  
1
  • IDAUniProtKB
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAInterPro 2 GO
Metabolic processdefinition[GO:0008152]  
1
  • IDAGOC
Negative regulation of bone mineralizationdefinition[GO:0030502]  
1
  • IMPUniProtKB
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • IMPUniProtKB
Positive regulation of calcium ion transportdefinition[GO:0051928]  
1
  • IDAUniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • IDAUniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IMPUniProtKB
Positive regulation of monocyte chemotaxisdefinition[GO:0090026]  
1
  • IDAUniProtKB
Positive regulation of osteoclast differentiationdefinition[GO:0045672]  
1
  • IMPUniProtKB
Response to woundingdefinition[GO:0009611]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+1230  
Cytokine-cytokine receptor interaction  hsa04060+1230  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CCR1
GenomeRNAi: 1230
PRO: PR:P32246
Chemistry
GuidetoPHARMACOLOGY: 58