CCR7 - C-C chemokine receptor type 7 - human protein (Function)
 
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CCR7 »  C-C chemokine receptor type 7  (CCR-7)
 
Protein also known as:  Epstein-Barr virus-induced G-protein coupled receptor 1 (EBI1); CD antigen CD197.
Gene name:  CCR7
Entry whose protein(s) existence is based on evidence at protein level
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1 147 1
GENE REF ISO

Function

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Overview 
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.  
  • CuratedUniProtKB
GO molecular function 
C-C chemokine receptor activitydefinition[GO:0016493]  
  • ISSOrtholog Curator
C-C motif chemokine 19 receptor activitydefinition[GO:0038117]  
1
  • IDAUniProtKB
C-C motif chemokine 21 receptor activitydefinition[GO:0038121]  
1
  • IDAUniProtKB
Chemokine (C-C motif) ligand 19 bindingdefinition[GO:0035757]  
1
  • IPIBHF-UCL
Chemokine (C-C motif) ligand 21 bindingdefinition[GO:0035758]  
1
  • IPIBHF-UCL
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASBHF-UCL
GO biological process 
Activation of Rho GTPase activitydefinition[GO:0032862]  
1
  • ICBHF-UCL
Cellular response to cytokine stimulusdefinition[GO:0071345]  
1
  • IDABHF-UCL
Chemokine (C-C motif) ligand 19 signaling pathwaydefinition[GO:0038115]  
1
  • IDAGOC
Chemokine (C-C motif) ligand 21 signaling pathwaydefinition[GO:0038116]  
1
  • IDAGOC
Chemokine-mediated signaling pathwaydefinition[GO:0070098]  
  • ISSOrtholog Curator
Dendritic cell chemotaxisdefinition[GO:0002407]  
1
  • ICBHF-UCL
Establishment of T cell polaritydefinition[GO:0001768]  
1
  • ICBHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASBHF-UCL
Immune responsedefinition[GO:0006955] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
1
  • NASBHF-UCL
Interleukin-12 secretiondefinition[GO:0072610]  
  • ISSOrtholog Curator
Lymphocyte migration into lymph nodedefinition[GO:0097022]  
1
  • TASBHF-UCL
Mature dendritic cell differentiationdefinition[GO:0097029]  
  • ISSOrtholog Curator
Myeloid dendritic cell chemotaxisdefinition[GO:0002408]  
2
  • ICBHF-UCL
Negative regulation of leukocyte apoptotic processdefinition[GO:2000107]  
1
  • ICBHF-UCL
Negative thymic T cell selectiondefinition[GO:0045060] silver  
  • IEAOrtholog Compara
Positive regulation of actin filament polymerizationdefinition[GO:0030838]  
1
  • ICBHF-UCL
Positive regulation of cell adhesiondefinition[GO:0045785]  
1
  • ICBHF-UCL
Positive regulation of cell motilitydefinition[GO:2000147]  
1
  • ICBHF-UCL
Positive regulation of cell-matrix adhesiondefinition[GO:0001954]  
1
  • ICBHF-UCL
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • TASPINC
Positive regulation of dendritic cell antigen processing and presentationdefinition[GO:0002606]  
  • ISSOrtholog Curator
Positive regulation of dendritic cell chemotaxisdefinition[GO:2000510]  
  • ISSOrtholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • ICBHF-UCL
Positive regulation of filopodium assemblydefinition[GO:0051491]  
1
  • ICBHF-UCL
Positive regulation of glycoprotein biosynthetic process involved in immunological synapse formationdefinition[GO:2000526]  
  • ISSOrtholog Curator
Positive regulation of humoral immune responsedefinition[GO:0002922]  
  • ISSOrtholog Curator
Positive regulation of hypersensitivitydefinition[GO:0002885]  
  • ISSOrtholog Curator
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • ICBHF-UCL
Positive regulation of immunological synapse formationdefinition[GO:2000522]  
  • ISSOrtholog Curator
Positive regulation of interleukin-12 productiondefinition[GO:0032735]  
  • ISSOrtholog Curator
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • ICBHF-UCL
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
2
  • ICBHF-UCL
Positive regulation of protein kinase activitydefinition[GO:0045860]  
2
  • ICBHF-UCL
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
2
  • ICBHF-UCL
Positive regulation of pseudopodium assemblydefinition[GO:0031274]  
1
  • ICBHF-UCL
Positive regulation of T cell costimulationdefinition[GO:2000525]  
  • ISSOrtholog Curator
Positive regulation of T cell receptor signaling pathwaydefinition[GO:0050862] silver  
  • IEAOrtholog Compara
Regulation of dendritic cell dendrite assemblydefinition[GO:2000547]  
  • ISSOrtholog Curator
Regulation of interferon-gamma productiondefinition[GO:0032649]  
  • ISSOrtholog Curator
Regulation of interleukin-1 beta secretiondefinition[GO:0050706]  
  • ISSOrtholog Curator
Release of sequestered calcium ion into cytosoldefinition[GO:0051209]  
1
  • ICBHF-UCL
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to nitric oxidedefinition[GO:0071731]  
1
  • ICBHF-UCL
Response to prostaglandin Edefinition[GO:0034695]  
1
  • ICBHF-UCL
Ruffle organizationdefinition[GO:0031529]  
1
  • ICBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+1236  
Cytokine-cytokine receptor interaction  hsa04060+1236  
According to Reactome, this protein belongs to the following pathways:
Chemokine receptors bind chemokines  REACT_15344  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C-C_chemokine_receptor_type_7
GenomeRNAi: 1236
PRO: PR:P32248
Chemistry
GuidetoPHARMACOLOGY: 64