GPR183 - G-protein coupled receptor 183 - human protein (Function)
 
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GPR183 »  G-protein coupled receptor 183
 
Protein also known as:  Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2).
Gene name:  GPR183
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols. Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses. Promotes activated B-cell localization in the outer follicle and interfollicular regions. Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Signals constitutively through G(i)-alpha, but not through G(s)-alpha or G(q)-alpha. Signals constitutively also via MAPK1/3 (ERK1/2).  
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  • CuratedUniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
Oxysterol bindingdefinition[GO:0008142]  
1
  • IDAUniProtKB
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDAUniProtKB
Humoral immune responsedefinition[GO:0006959]  
  • ISSOrtholog Curator
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Mature B cell differentiation involved in immune responsedefinition[GO:0002313]  
  • ISSOrtholog Curator
Positive regulation of B cell proliferationdefinition[GO:0030890]  
1
  • IDAUniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IDAUniProtKB
Note 
GSK682753A (8-[(2E)-3-(4-chlorophenyl)prop-2-enoyl]-3-[(3,4-dichlorophenyl)methyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one), an inverse agonist, selectively inhibits the constitutive activity of GPR183 with high potency and efficacy (PubMed21673108).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Adaptive immunity  definition   [KW-1064]
Immunity  definition   [KW-0391]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GPR183
GenomeRNAi: 1880
PRO: PR:P32249
Chemistry
GuidetoPHARMACOLOGY: 81