CXCR5 - C-X-C chemokine receptor type 5 - human protein (Function)
 
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CXCR5 »  C-X-C chemokine receptor type 5  (CXC-R5)
 
Protein also known as:  Monocyte-derived receptor 15 (MDR-15); CD antigen CD185.
Gene name:  CXCR5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 52 2
GENE REF ISO

Function

 show evidences
Overview 
Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.  
  • CuratedUniProtKB
GO molecular function 
C-X-C chemokine receptor activitydefinition[GO:0016494] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
B cell activationdefinition[GO:0042113]  
  • IEAUniProtKB KW
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Chemotaxisdefinition[GO:0006935] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Lymph node developmentdefinition[GO:0048535] silver  
  • IEAOrtholog Compara
Positive regulation of cytokinesisdefinition[GO:0032467]  
1
  • IMPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Chemokine signaling pathway  hsa04062+643  
Cytokine-cytokine receptor interaction  hsa04060+643  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
B-cell activation  definition   [KW-0075]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CXCR5
GenomeRNAi: 643
PRO: PR:P32302
Chemistry
GuidetoPHARMACOLOGY: 72