DCTD - Deoxycytidylate deaminase - human protein (Function)
 
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Protein
Gene
References

 
DCTD »  Deoxycytidylate deaminase   [ EC 3.5.4.12 ]
 
Protein also known as:  dCMP deaminase.
Gene name:  DCTD
Entry whose protein(s) existence is based on evidence at protein level
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1 13 2
GENE REF ISO

Function

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Overview 
Supplies the nucleotide substrate for thymidylate synthetase.  
  • CuratedUniProtKB
GO molecular function 
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Nucleotide biosynthetic processdefinition[GO:0009165]  
  • IEAUniProtKB KW
Pyrimidine nucleotide metabolic processdefinition[GO:0006220]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.4.12: dCMP + H(2)O dUMP + NH(3).  
  • CuratedUniProtKB
It requires the following cofactor
Zinc.  
  • CuratedUniProtKB
It is regulated in the following manner
Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+1635  
Pyrimidine metabolism  hsa00240+1635  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Nucleotide biosynthesis  definition   [KW-0545]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P32321
Other
GenomeRNAi: 1635
PRO: PR:P32321