ELF1 - ETS-related transcription factor Elf-1 - human protein (Function)
 
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ELF1 »  ETS-related transcription factor Elf-1
 
Protein also known as:  E74-like factor 1.
Gene name:  ELF1
Family name: ETS
Entry whose protein(s) existence is based on evidence at protein level
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1 45 2
GENE REF ISO

Function

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Overview 
Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDANTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • IDANTNU_SB
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981] silver  
  • IBARefGenome
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
GO biological process 
Cell differentiationdefinition[GO:0030154] silver  
  • IBARefGenome
Negative regulation of T cell receptor signaling pathwaydefinition[GO:0050860] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
3
  • IDAUniProtKB
  • IDANTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
2
  • IDAUniProtKB
Regulation of cytokine productiondefinition[GO:0001817] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IBARefGenome
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1997
PRO: PR:P32519