ACSL1 - Long-chain-fatty-acid--CoA ligase 1 - human protein (Function)
 
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ACSL1 »  Long-chain-fatty-acid--CoA ligase 1   [ EC 6.2.1.3 ]
 
Protein also known as:  Long-chain fatty acid-CoA ligase 2.
Gene name:  ACSL1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 3
GENE REF ISO

Function

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Overview 
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Long-chain fatty acid-CoA ligase activitydefinition[GO:0004467]  
2
  • IDAUniProtKB
GO biological process 
Adiponectin-activated signaling pathwaydefinition[GO:0033211] silver  
  • IEAOrtholog Compara
Lipid biosynthetic processdefinition[GO:0008610]  
1
  • IDAUniProtKB
Long-chain fatty acid importdefinition[GO:0044539]  
1
  • IDAUniProtKB
Long-chain fatty acid metabolic processdefinition[GO:0001676]  
1
  • IDAUniProtKB
Positive regulation of protein serine/threonine kinase activitydefinition[GO:0071902] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to oleic aciddefinition[GO:0034201] silver  
  • IEAOrtholog Compara
Response to organic cyclic compounddefinition[GO:0014070] silver  
  • IEAOrtholog Compara
Xenobiotic catabolic processdefinition[GO:0042178] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 6.2.1.3: ATP + a long-chain fatty acid + CoA AMP + diphosphate + an acyl-CoA.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+2180  
Fatty acid metabolism  hsa00071+2180  
Metabolic pathways  hsa01100+2180  
Peroxisome  hsa04146+2180  
PPAR signaling pathway  hsa03320+2180  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Fatty acid metabolism  definition   [KW-0276]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ACSL1
GenomeRNAi: 2180
PRO: PR:P33121