GUCY1A2 - Guanylate cyclase soluble subunit alpha-2 - human protein (Function)
 
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GUCY1A2 »  Guanylate cyclase soluble subunit alpha-2   [ EC 4.6.1.2 ]  (GCS-alpha-2)
 
Gene name:  GUCY1A2
Entry whose protein(s) existence is based on evidence at protein level
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1 34 3
GENE REF ISO

Function

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Overview 
Has guanylyl cyclase on binding to the beta-1 subunit.  
  • CuratedUniProtKB
Isoform  Iso 2   Acts as a negative regulator of guanylyl cyclase activity as it forms non-functional heterodimers with the beta subunits.  
  • CuratedUniProtKB
GO molecular function 
GTP bindingdefinition[GO:0005525]  
  • IEAUniProtKB KW
Guanylate cyclase activitydefinition[GO:0004383]  
  • IEAEC 2 GO
Heme bindingdefinition[GO:0020037] silver  
  • IEAInterPro 2 GO
GO biological process 
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Positive regulation of cGMP biosynthetic processdefinition[GO:0030828] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.6.1.2: GTP 3',5'-cyclic GMP + diphosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by nitric oxide in the presence of magnesium or manganese ions.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+2977  
Long-term depression  hsa04730+2977  
Purine metabolism  hsa00230+2977  
Salivary secretion  hsa04970+2977  
Vascular smooth muscle contraction  hsa04270+2977  
According to Reactome, this protein belongs to the following pathway:
Hemostasis  REACT_604  
Note 
There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.  
  • CuratedUniProtKB
 

Keywords

Biological process 
cGMP biosynthesis  definition   [KW-0141]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GUCY1A2
GenomeRNAi: 2977
PRO: PR:P33402