ABCC1 - Multidrug resistance-associated protein 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
ABCC1 »  Multidrug resistance-associated protein 1
 
Protein also known as:  ATP-binding cassette sub-family C member 1.
Gene name:  ABCC1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 68 9
GENE REF ISO

Function

 show evidences
Overview 
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.208.8  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
ATPase activitydefinition[GO:0016887]  
1
  • UniProtKB
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
1
  • InterPro 2 GO
Transporter activitydefinition[GO:0005215]  
1
  • PINC
GO biological process 
Response to drugdefinition[GO:0042493]  
1
  • PINC
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+4363  
Vitamin digestion and absorption  hsa04977+4363  
According to Reactome, this protein belongs to the following pathways:
ABC-family proteins mediated transport  REACT_15480  
Cobalamin (Cbl, vitamin B12) transport and metabolism  REACT_163862  
Synthesis of Leukotrienes (LT) and Eoxins (EX)  REACT_150420  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCC1
GenomeRNAi: 4363
PRO: PR:P33527