TTK - Dual specificity protein kinase TTK - human protein (Function)
 
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TTK »  Dual specificity protein kinase TTK   [ EC 2.7.12.1 ]
 
Protein also known as:  Phosphotyrosine picked threonine-protein kinase (PYT).
Gene name:  TTK
Entry whose protein(s) existence is based on evidence at protein level
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1 98 2
GENE REF ISO

Function

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Overview 
Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
  • IEAEC 2 GO
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • IEAUniProtKB KW
GO biological process 
Mitotic spindle assembly checkpointdefinition[GO:0007094]  
1
  • TASPINC
Mitotic spindle organizationdefinition[GO:0007052]  
1
  • TASPINC
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • TASGOC
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • TASPINC
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • TASBHF-UCL
Spindle organizationdefinition[GO:0007051]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by the ATP-competitive kinase inhibitor, SP600125.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Cell cycle  hsa04110+7272  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TTK_(gene)
GenomeRNAi: 7272
PRO: PR:P33981
Chemistry
GuidetoPHARMACOLOGY: 2264