MPI - Mannose-6-phosphate isomerase - human protein (Function)
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MPI »  Mannose-6-phosphate isomerase   [ EC ]
Protein also known as:  Phosphomannose isomerase (PMI).
Gene name:  MPI
Entry whose protein(s) existence is based on evidence at protein level
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Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.  
  • CuratedUniProtKB
GO molecular function 
Mannose-6-phosphate isomerase activitydefinition[GO:0004476]  
  • IEAEC 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
GDP-mannose biosynthetic processdefinition[GO:0009298]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC D-mannose 6-phosphate D-fructose 6-phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Amino sugar and nucleotide sugar metabolism  hsa00520+4351  
Fructose and mannose metabolism  hsa00051+4351  
Metabolic pathways  hsa01100+4351  
According to Reactome, this protein belongs to the following pathways:
Metabolism of proteins  REACT_17015  
Signal Transduction  REACT_111102  


Molecular function 
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GenomeRNAi: 4351
PRO: PR:P34949