PTGER1 - Prostaglandin E2 receptor EP1 subtype - human protein (Function)
 
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PTGER1 »  Prostaglandin E2 receptor EP1 subtype  (PGE receptor EP1 subtype)
 
Protein also known as:  Prostanoid EP1 receptor.
Gene name:  PTGER1
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 36 1
GENE REF ISO

Function

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Overview 
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.9.1  
GO molecular function 
Prostaglandin E receptor activitydefinition[GO:0004957] silver  
  • IEAOrtholog Compara
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+5731  
Neuroactive ligand-receptor interaction  hsa04080+5731  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EP1_receptor
GenomeRNAi: 5731
PRO: PR:P34995
Chemistry
GuidetoPHARMACOLOGY: 340