CRHR1 - Corticotropin-releasing factor receptor 1 - human protein (Function)
 
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CRHR1 »  Corticotropin-releasing factor receptor 1  (CRF-R1)
 
Protein also known as:  Corticotropin-releasing hormone receptor 1 (CRH-R1).
Gene name:  CRHR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 140 5
GENE REF ISO

Function

 show evidences
Overview 
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.  
5
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.3  
GO molecular function 
Corticotrophin-releasing factor receptor activitydefinition[GO:0015056]  
1
  • UniProtKB
Corticotropin-releasing hormone bindingdefinition[GO:0051424] silver  
1
  • Ortholog Compara
Corticotropin-releasing hormone receptor activitydefinition[GO:0043404] silver  
1
  • Ortholog Compara
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • PINC
Adrenal gland developmentdefinition[GO:0030325] silver  
1
  • Ortholog Compara
Behavioral response to cocainedefinition[GO:0048148] silver  
1
  • Ortholog Compara
Behavioral response to ethanoldefinition[GO:0048149] silver  
1
  • Ortholog Compara
Behavioral response to paindefinition[GO:0048266] silver  
1
  • Ortholog Compara
Cellular response to corticotropin-releasing hormone stimulusdefinition[GO:0071376]  
1
  • UniProtKB
Corticotropin secretiondefinition[GO:0051458]  
1
  • Ortholog Curator
Epithelial cell differentiationdefinition[GO:0030855] silver  
1
  • Ortholog Compara
Fear responsedefinition[GO:0042596] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565]  
1
  • PINC
General adaptation syndrome, behavioral processdefinition[GO:0051867] silver  
1
  • Ortholog Compara
Hormone-mediated signaling pathwaydefinition[GO:0009755] silver  
1
  • Ortholog Compara
Hypothalamus developmentdefinition[GO:0021854] silver  
1
  • Ortholog Compara
Immune responsedefinition[GO:0006955]  
1
  • PINC
Locomotory exploration behaviordefinition[GO:0035641] silver  
1
  • Ortholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
1
  • Ortholog Compara
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
Negative regulation of epinephrine secretiondefinition[GO:0032811] silver  
1
  • Ortholog Compara
Negative regulation of feeding behaviordefinition[GO:2000252] silver  
1
  • Ortholog Compara
Negative regulation of neuron deathdefinition[GO:1901215] silver  
1
  • Ortholog Compara
Negative regulation of voltage-gated calcium channel activitydefinition[GO:1901386]  
1
  • UniProtKB
Neuropeptide signaling pathwaydefinition[GO:0007218] silver  
1
  • Ortholog Compara
Parturitiondefinition[GO:0007567]  
1
  • PINC
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
1
  • Ortholog Compara
Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • UniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
1
  • Ortholog Compara
Positive regulation of mast cell degranulationdefinition[GO:0043306] silver  
1
  • Ortholog Compara
Regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010578]  
1
  • UniProtKB
Regulation of corticosterone secretiondefinition[GO:2000852]  
1
  • Ortholog Curator
Response to electrical stimulusdefinition[GO:0051602] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to immobilization stressdefinition[GO:0035902] silver  
1
  • Ortholog Compara
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Long-term depression  hsa04730+1394  
Neuroactive ligand-receptor interaction  hsa04080+1394  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  REACT_18372  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Corticotropin_releasing_hormone_receptor_1
GenomeRNAi: 1394
PRO: PR:P34998
Chemistry
GuidetoPHARMACOLOGY: 212