CRHR1 - Corticotropin-releasing factor receptor 1 - human protein (Function)
 
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CRHR1 »  Corticotropin-releasing factor receptor 1  (CRFR-1)
 
Protein also known as:  Corticotropin-releasing hormone receptor 1 (CRH-R1).
Gene name:  CRHR1
Entry whose protein(s) existence is based on evidence at protein level
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1 135 5
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.4.3  
GO molecular function 
Corticotrophin-releasing factor receptor activitydefinition[GO:0015056]  
1
  • IDAUniProtKB
Corticotropin-releasing hormone bindingdefinition[GO:0051424] silver  
  • IEAOrtholog Compara
Corticotropin-releasing hormone receptor activitydefinition[GO:0043404] silver  
  • IEAOrtholog Compara
G-protein alpha-subunit bindingdefinition[GO:0001965] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • TASPINC
Adrenal gland developmentdefinition[GO:0030325] silver  
  • IEAOrtholog Compara
Behavioral response to cocainedefinition[GO:0048148] silver  
  • IEAOrtholog Compara
Behavioral response to ethanoldefinition[GO:0048149] silver  
  • IEAOrtholog Compara
Behavioral response to paindefinition[GO:0048266] silver  
  • IEAOrtholog Compara
Cellular response to corticotropin-releasing hormone stimulusdefinition[GO:0071376]  
1
  • IDAUniProtKB
Corticotropin secretiondefinition[GO:0051458]  
  • ISSOrtholog Curator
Epithelial cell differentiationdefinition[GO:0030855] silver  
  • IEAOrtholog Compara
Fear responsedefinition[GO:0042596] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565]  
1
  • NASPINC
General adaptation syndrome, behavioral processdefinition[GO:0051867] silver  
  • IEAOrtholog Compara
Hormone-mediated signaling pathwaydefinition[GO:0009755] silver  
  • IEAOrtholog Compara
Hypothalamus developmentdefinition[GO:0021854] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Locomotory exploration behaviordefinition[GO:0035641] silver  
  • IEAOrtholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
  • IEAOrtholog Compara
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Negative regulation of epinephrine secretiondefinition[GO:0032811] silver  
  • IEAOrtholog Compara
Negative regulation of feeding behaviordefinition[GO:2000252] silver  
  • IEAOrtholog Compara
Negative regulation of neuron deathdefinition[GO:1901215] silver  
  • IEAOrtholog Compara
Negative regulation of voltage-gated calcium channel activitydefinition[GO:1901386]  
1
  • IDAUniProtKB
Neuropeptide signaling pathwaydefinition[GO:0007218] silver  
  • IEAOrtholog Compara
Parturitiondefinition[GO:0007567]  
1
  • TASPINC
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
  • IEAOrtholog Compara
Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • IDAUniProtKB
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Positive regulation of mast cell degranulationdefinition[GO:0043306] silver  
  • IEAOrtholog Compara
Regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010578]  
1
  • IMPUniProtKB
Regulation of corticosterone secretiondefinition[GO:2000852]  
  • ISSOrtholog Curator
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to immobilization stressdefinition[GO:0035902] silver  
  • IEAOrtholog Compara
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Long-term depression  hsa04730+1394  
Neuroactive ligand-receptor interaction  hsa04080+1394  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  REACT_18372  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Corticotropin_releasing_hormone_receptor_1
GenomeRNAi: 1394
PRO: PR:P34998
Chemistry
GuidetoPHARMACOLOGY: 212