PRSS3 - Trypsin-3 - human protein (Function)
 
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PRSS3 »  Trypsin-3   [ EC 3.4.21.4 ]
 
Protein also known as:  Serine protease 4.
Gene name:  PRSS3
Family name: Peptidase S1
Entry whose protein(s) existence is based on evidence at protein level
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1 42 5
GENE REF ISO

Function

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Overview 
Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5.  
2
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • IDAUniProtKB
Isoform  Iso 3   Serine-type peptidase activitydefinition[GO:0008236]  
1
  • IDAUniProtKB
GO biological process 
Digestiondefinition[GO:0007586]  
2
  • TASUniProtKB
Endothelial cell migrationdefinition[GO:0043542]  
1
  • IMPUniProtKB
Proteolysisdefinition[GO:0006508]  
3
  • IDAGOC
  • NASUniProtKB
Zymogen activationdefinition[GO:0031638]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.21.4: Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 calcium ion per subunit.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Influenza A  hsa05164+5646  
Neuroactive ligand-receptor interaction  hsa04080+5646  
Pancreatic secretion  hsa04972+5646  
Protein digestion and absorption  hsa04974+5646  
According to Reactome, this protein belongs to the following pathways:
Alpha-defensins  REACT_115574  
Cobalamin (Cbl, vitamin B12) transport and metabolism  REACT_163862  
 

Keywords

Biological process 
Digestion  definition   [KW-0222]
Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Serine protease  definition   [KW-0720]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 5646
PRO: PR:P35030