CA5A - Carbonic anhydrase 5A, mitochondrial - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CA5A »  Carbonic anhydrase 5A, mitochondrial   [ EC 4.2.1.1 ]
 
Protein also known as:  Carbonate dehydratase VA.
Gene name:  CA5A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 20 1
GENE REF ISO

Function

 show evidences
Overview 
Reversible hydration of carbon dioxide. Low activity.  
  • CuratedUniProtKB
GO molecular function 
Carbonate dehydratase activitydefinition[GO:0004089]  
  • IEAEC 2 GO
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
One-carbon metabolic processdefinition[GO:0006730] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.1: H(2)CO(3) CO(2) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Zinc (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt).  
7
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Nitrogen metabolism  hsa00910+763  
According to Reactome, this protein belongs to the following pathway:
Reversible hydration of carbon dioxide  REACT_121123  
 

Biophysicochemical properties

Kinetic parameters
KM 10.0 mM for CO(2)

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P35218
Other
GenomeRNAi: 763
PRO: PR:P35218