CTNNA1 - Catenin alpha-1 - human protein (Function)
 
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CTNNA1 »  Catenin alpha-1
 
Protein also known as:  Renal carcinoma antigen NY-REN-13.
Gene name:  CTNNA1
Family name: Vinculin/alpha-catenin
Entry whose protein(s) existence is based on evidence at protein level
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1 131 3
GENE REF ISO

Function

 show evidences
Overview 
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.  
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015] silver  
  • IEAOrtholog Compara
Beta-catenin bindingdefinition[GO:0008013]  
2
  • IPIBHF-UCL
Cadherin bindingdefinition[GO:0045296]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
Gamma-catenin bindingdefinition[GO:0045295]  
2
  • IPIBHF-UCL
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIHGNC
Structural molecule activitydefinition[GO:0005198] silver  
  • IEAInterPro 2 GO
Vinculin bindingdefinition[GO:0017166]  
1
  • IPIUniProtKB
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Apical junction assemblydefinition[GO:0043297]  
1
  • NASUniProtKB
Axon regenerationdefinition[GO:0031103] silver  
  • IEAOrtholog Compara
Cell adhesiondefinition[GO:0007155]  
1
  • NASPINC
Cellular protein localizationdefinition[GO:0034613] silver  
  • IEAOrtholog Compara
Cellular response to indole-3-methanoldefinition[GO:0071681]  
1
  • IDAUniProtKB
Epithelial cell-cell adhesiondefinition[GO:0090136] silver  
  • IEAOrtholog Compara
Establishment or maintenance of cell polaritydefinition[GO:0007163] silver  
  • IEAOrtholog Compara
Gap junction assemblydefinition[GO:0016264] silver  
  • IEAOrtholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell motilitydefinition[GO:2000146] silver  
  • IEAOrtholog Compara
Negative regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001240] silver  
  • IEAOrtholog Compara
Negative regulation of integrin-mediated signaling pathwaydefinition[GO:2001045] silver  
  • IEAOrtholog Compara
Negative regulation of neuroblast proliferationdefinition[GO:0007406] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Ovarian follicle developmentdefinition[GO:0001541] silver  
  • IEAOrtholog Compara
Positive regulation of extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:2001241] silver  
  • IEAOrtholog Compara
Positive regulation of smoothened signaling pathwaydefinition[GO:0045880] silver  
  • IEAOrtholog Compara
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Response to estrogendefinition[GO:0043627] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+1495  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+1495  
Bacterial invasion of epithelial cells  hsa05100+1495  
Endometrial cancer  hsa05213+1495  
Leukocyte transendothelial migration  hsa04670+1495  
Pathways in cancer  hsa05200+1495  
Tight junction  hsa04530+1495  
According to Reactome, this protein belongs to the following pathways:
Adherens junctions interactions  REACT_19195  
CDO in myogenesis  REACT_21402  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links