CTNNB1 - Catenin beta-1 - human protein (Function)
 
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CTNNB1 »  Catenin beta-1
 
Protein also known as:  Beta-catenin.
Gene name:  CTNNB1
Family name: Beta-catenin
Entry whose protein(s) existence is based on evidence at protein level
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1 1410 2
GENE REF ISO

Function

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Overview 
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.  
8
  • CuratedUniProtKB
GO molecular function 
Alpha-catenin bindingdefinition[GO:0045294]  
2
  • IPIBHF-UCL
Androgen receptor bindingdefinition[GO:0050681]  
1
  • NASUniProtKB
Cadherin bindingdefinition[GO:0045296]  
3
  • IPIUniProtKB
  • IPIBHF-UCL
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Double-stranded DNA bindingdefinition[GO:0003690] silver  
  • IEAOrtholog Compara
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Estrogen receptor bindingdefinition[GO:0030331]  
1
  • IPIBHF-UCL
I-SMAD bindingdefinition[GO:0070411]  
1
  • IPIBHF-UCL
Ion channel bindingdefinition[GO:0044325]  
1
  • IPIBHF-UCL
Ionotropic glutamate receptor bindingdefinition[GO:0035255] silver  
  • IEAOrtholog Compara
Kinase bindingdefinition[GO:0019900]  
1
  • IPIBHF-UCL
Nuclear hormone receptor bindingdefinition[GO:0035257]  
2
  • TASAgBase
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
90
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein C-terminus bindingdefinition[GO:0008022]  
2
  • IPIUniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901] silver  
  • IBARefGenome
Protein phosphatase bindingdefinition[GO:0019903]  
2
  • IPIUniProtKB
R-SMAD bindingdefinition[GO:0070412]  
1
  • IPIBHF-UCL
Repressing transcription factor bindingdefinition[GO:0070491] silver  
  • IEAOrtholog Compara
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • IPIBHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871]  
1
  • NASPINC
SMAD bindingdefinition[GO:0046332]  
1
  • IPIBHF-UCL
Structural molecule activitydefinition[GO:0005198] silver  
  • IBARefGenome
Transcription coactivator activitydefinition[GO:0003713]  
3
  • IMPUniProtKB
  • IDABHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
2
  • IPIBHF-UCL
  • TASAgBase
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
2
  • IDAUniProtKB
GO biological process 
Adherens junction assemblydefinition[GO:0034333]  
2
  • IMPBHF-UCL
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • NASUniProtKB
Anterior/posterior axis specificationdefinition[GO:0009948] silver  
  • IEAOrtholog Compara
Bone resorptiondefinition[GO:0045453] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IBARefGenome
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
2
  • IDAUniProtKB
Canonical Wnt signaling pathway involved in negative regulation of apoptotic processdefinition[GO:0044336]  
1
  • IMPBHF-UCL
Canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationdefinition[GO:0061324]  
  • ISSOrtholog Curator
Canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitiondefinition[GO:0044334]  
1
  • IMPBHF-UCL
Cell adhesiondefinition[GO:0007155]  
1
  • IMPBHF-UCL
Cell fate specificationdefinition[GO:0001708] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Cell-cell adhesiondefinition[GO:0016337]  
1
  • IMPBHF-UCL
Cell-matrix adhesiondefinition[GO:0007160] silver  
  • IBARefGenome
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • IMPBHF-UCL
Cellular response to indole-3-methanoldefinition[GO:0071681]  
1
  • IDAUniProtKB
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Central nervous system vasculogenesisdefinition[GO:0022009] silver  
  • IBARefGenome
Cytoskeletal anchoring at plasma membranedefinition[GO:0007016] silver  
  • IBARefGenome
Determination of dorsal/ventral asymmetrydefinition[GO:0048262] silver  
  • IBARefGenome
Dorsal/ventral axis specificationdefinition[GO:0009950] silver  
  • IBARefGenome
Ectoderm developmentdefinition[GO:0007398] silver  
  • IBARefGenome
Embryonic axis specificationdefinition[GO:0000578] silver  
  • IBARefGenome
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
  • IEAOrtholog Compara
Embryonic foregut morphogenesisdefinition[GO:0048617] silver  
  • IBARefGenome
Embryonic forelimb morphogenesisdefinition[GO:0035115] silver  
  • IEAOrtholog Compara
Embryonic heart tube developmentdefinition[GO:0035050] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
  • IBARefGenome
Embryonic skeletal limb joint morphogenesisdefinition[GO:0036023]  
  • ISSOrtholog Curator
Endodermal cell fate commitmentdefinition[GO:0001711] silver  
  • IBARefGenome
Endothelial tube morphogenesisdefinition[GO:0061154]  
1
  • IMPBHF-UCL
Epithelial cell differentiation involved in prostate gland developmentdefinition[GO:0060742] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
1
  • TASHGNC
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
  • IEAOrtholog Compara
Fungiform papilla formationdefinition[GO:0061198] silver  
  • IEAOrtholog Compara
Gastrulation with mouth forming seconddefinition[GO:0001702] silver  
  • IBARefGenome
Genitalia morphogenesisdefinition[GO:0035112] silver  
  • IEAOrtholog Compara
Glial cell fate determinationdefinition[GO:0007403] silver  
  • IBARefGenome
Hair cell differentiationdefinition[GO:0035315]  
1
  • TASBHF-UCL
Hair follicle morphogenesisdefinition[GO:0031069] silver  
  • IBARefGenome
Hair follicle placode formationdefinition[GO:0060789] silver  
  • IBARefGenome
Hindbrain developmentdefinition[GO:0030902] silver  
  • IBARefGenome
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Layer formation in cerebral cortexdefinition[GO:0021819] silver  
  • IEAOrtholog Compara
Lens morphogenesis in camera-type eyedefinition[GO:0002089] silver  
  • IEAOrtholog Compara
Liver developmentdefinition[GO:0001889] silver  
  • IBARefGenome
Lung cell differentiationdefinition[GO:0060479] silver  
  • IBARefGenome
Lung inductiondefinition[GO:0060492] silver  
  • IBARefGenome
Lung-associated mesenchyme developmentdefinition[GO:0060484] silver  
  • IBARefGenome
Male genitalia developmentdefinition[GO:0030539] silver  
  • IBARefGenome
Mesenchymal cell proliferation involved in lung developmentdefinition[GO:0060916] silver  
  • IBARefGenome
Mesenchymal to epithelial transition involved in metanephros morphogenesisdefinition[GO:0003337] silver  
  • IBARefGenome
Midgut developmentdefinition[GO:0007494] silver  
  • IEAOrtholog Compara
Myoblast differentiationdefinition[GO:0045445] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic signaling pathwaydefinition[GO:2001234] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Negative regulation of chondrocyte differentiationdefinition[GO:0032331] silver  
  • IBARefGenome
Negative regulation of heart induction by canonical Wnt signaling pathwaydefinition[GO:0003136] silver  
  • IBARefGenome
Negative regulation of oligodendrocyte differentiationdefinition[GO:0048715] silver  
  • IEAOrtholog Compara
Negative regulation of osteoclast differentiationdefinition[GO:0045671] silver  
  • IBARefGenome
Negative regulation of protein sumoylationdefinition[GO:0033234]  
1
  • IDAUniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IBARefGenome
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPUniProtKB
Nephron tubule formationdefinition[GO:0072079] silver  
  • IBARefGenome
Neural plate developmentdefinition[GO:0001840] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IBARefGenome
Oocyte developmentdefinition[GO:0048599] silver  
  • IBARefGenome
Osteoclast differentiationdefinition[GO:0030316] silver  
  • IEAOrtholog Compara
Oviduct developmentdefinition[GO:0060066] silver  
  • IEAOrtholog Compara
Pancreas developmentdefinition[GO:0031016] silver  
  • IBARefGenome
Patterning of blood vesselsdefinition[GO:0001569]  
1
  • ICBHF-UCL