CTNNB1 - Catenin beta-1 - human protein (Function)
 
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CTNNB1 »  Catenin beta-1
 
Protein also known as:  Beta-catenin.
Gene name:  CTNNB1
Family name: Beta-catenin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed17524503, PubMed18077326, PubMed18086858, PubMed18957423, PubMed21262353, PubMed22647378, PubMed22699938, PubMed22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).  
10
  • UniProtKB
GO molecular function 
Alpha-catenin bindingdefinition[GO:0045294]  
3
  • BHF-UCL
Androgen receptor bindingdefinition[GO:0050681]  
1
  • UniProtKB
Cadherin bindingdefinition[GO:0045296]  
3
  • UniProtKB
  • BHF-UCL
Double-stranded DNA bindingdefinition[GO:0003690] silver  
1
  • Ortholog Compara
Enzyme bindingdefinition[GO:0019899]  
2
  • UniProtKB
  • BHF-UCL
Estrogen receptor bindingdefinition[GO:0030331]  
1
  • BHF-UCL
Euchromatin bindingdefinition[GO:1990188]  
1
  • BHF-UCL
I-SMAD bindingdefinition[GO:0070411]  
1
  • BHF-UCL
Ion channel bindingdefinition[GO:0044325]  
1
  • BHF-UCL
Ionotropic glutamate receptor bindingdefinition[GO:0035255] silver  
1
  • Ortholog Compara
Kinase bindingdefinition[GO:0019900]  
1
  • BHF-UCL
Nitric-oxide synthase bindingdefinition[GO:0050998] silver  
1
  • Ortholog Compara
Nuclear hormone receptor bindingdefinition[GO:0035257]  
2
  • AgBase
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
102
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein C-terminus bindingdefinition[GO:0008022]  
2
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein phosphatase bindingdefinition[GO:0019903]  
2
  • UniProtKB
R-SMAD bindingdefinition[GO:0070412]  
1
  • BHF-UCL
Repressing transcription factor bindingdefinition[GO:0070491] silver  
1
  • Ortholog Compara
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • BHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • Ortholog Compara
Signal transducer activitydefinition[GO:0004871] silver  
1
  • InterPro 2 GO
SMAD bindingdefinition[GO:0046332]  
1
  • BHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
3
  • UniProtKB
  • BHF-UCL
Transcription factor bindingdefinition[GO:0008134]  
2
  • BHF-UCL
  • AgBase
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
2
  • UniProtKB
GO biological process 
Adherens junction assemblydefinition[GO:0034333]  
2
  • BHF-UCL
Androgen receptor signaling pathwaydefinition[GO:0030521]  
1
  • UniProtKB
Anterior/posterior axis specificationdefinition[GO:0009948] silver  
1
  • Ortholog Compara
Bone resorptiondefinition[GO:0045453] silver  
1
  • Ortholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
1
  • Ortholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
2
  • UniProtKB
Canonical Wnt signaling pathway involved in negative regulation of apoptotic processdefinition[GO:0044336]  
1
  • BHF-UCL
Canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationdefinition[GO:0061324]  
1
  • Ortholog Curator
Canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transitiondefinition[GO:0044334]  
1
  • BHF-UCL
Cell adhesiondefinition[GO:0007155]  
1
  • BHF-UCL
Cell fate specificationdefinition[GO:0001708] silver  
1
  • Ortholog Compara
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cell-matrix adhesiondefinition[GO:0007160] silver  
1
  • Ortholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363]  
1
  • BHF-UCL
Cellular response to indole-3-methanoldefinition[GO:0071681]  
1
  • UniProtKB
Cellular response to insulin-like growth factor stimulusdefinition[GO:1990314] silver  
1
  • Ortholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
1
  • Ortholog Compara
Central nervous system vasculogenesisdefinition[GO:0022009] silver  
1
  • Ortholog Compara
Dorsal/ventral axis specificationdefinition[GO:0009950] silver  
1
  • Ortholog Compara
Ectoderm developmentdefinition[GO:0007398] silver  
1
  • Ortholog Compara
Embryonic axis specificationdefinition[GO:0000578] silver  
1
  • Ortholog Compara
Embryonic digit morphogenesisdefinition[GO:0042733] silver  
1
  • Ortholog Compara
Embryonic foregut morphogenesisdefinition[GO:0048617] silver  
1
  • Ortholog Compara
Embryonic forelimb morphogenesisdefinition[GO:0035115] silver  
1
  • Ortholog Compara
Embryonic heart tube developmentdefinition[GO:0035050] silver  
1
  • Ortholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
1
  • Ortholog Compara
Embryonic skeletal limb joint morphogenesisdefinition[GO:0036023]  
1
  • Ortholog Curator
Endodermal cell fate commitmentdefinition[GO:0001711] silver  
1
  • Ortholog Compara
Endothelial tube morphogenesisdefinition[GO:0061154]  
1
  • BHF-UCL
Epithelial cell differentiation involved in prostate gland developmentdefinition[GO:0060742] silver  
1
  • Ortholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
1
  • HGNC
Epithelial tube branching involved in lung morphogenesisdefinition[GO:0060441] silver  
1