IL13 - Interleukin-13 - human protein (Function)
 
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IL13 »  Interleukin-13
 
Gene name:  IL13
Family name: IL-4/IL-13
Entry whose protein(s) existence is based on evidence at protein level
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1 321 1
GENE REF ISO

Function

 show evidences
Overview 
Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Interleukin-13 receptor bindingdefinition[GO:0005144] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Cell-cell signalingdefinition[GO:0007267]  
1
  • ICUniProtKB
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
Cellular response to cytokine stimulusdefinition[GO:0071345] silver  
  • IEAOrtholog Compara
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Immune responsedefinition[GO:0006955] silver  
  • IEAInterPro 2 GO
Inflammatory responsedefinition[GO:0006954]  
1
  • TASPINC
Negative regulation of lung ciliated cell differentiationdefinition[GO:1901247]  
1
  • NASBHF-UCL
Negative regulation of transforming growth factor beta productiondefinition[GO:0071635] silver  
  • IEAOrtholog Compara
Positive regulation of B cell proliferationdefinition[GO:0030890] silver  
  • IEAOrtholog Compara
Positive regulation of connective tissue growth factor productiondefinition[GO:0032723] silver  
  • IEAOrtholog Compara
Positive regulation of immunoglobulin productiondefinition[GO:0002639] silver  
  • IEAOrtholog Compara
Positive regulation of lung goblet cell differentiationdefinition[GO:1901251]  
1
  • NASBHF-UCL
Positive regulation of macrophage activationdefinition[GO:0043032] silver  
  • IEAOrtholog Compara
Positive regulation of pancreatic stellate cell proliferationdefinition[GO:2000231] silver  
  • IEAOrtholog Compara
Positive regulation of protein secretiondefinition[GO:0050714] silver  
  • IEAOrtholog Compara
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Positive regulation of tyrosine phosphorylation of Stat6 proteindefinition[GO:0042526] silver  
  • IEAOrtholog Compara
Regulation of proton transportdefinition[GO:0010155] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Asthma  hsa05310+3596  
Cytokine-cytokine receptor interaction  hsa04060+3596  
Fc epsilon RI signaling pathway  hsa04664+3596  
Jak-STAT signaling pathway  hsa04630+3596  
Measles  hsa05162+3596  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_13
GenomeRNAi: 3596
PRO: PR:P35225