PHB - Prohibitin - human protein (Function)
 
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Protein
Gene
References

 
PHB »  Prohibitin
 
Gene name:  PHB
Family name: Prohibitin
Entry whose protein(s) existence is based on evidence at protein level
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1 126 2
GENE REF ISO

Function

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Overview 
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.  
2
  • UniProtKB
GO molecular function 
Complement component C3a bindingdefinition[GO:0001850]  
1
  • UniProtKB
Complement component C3b bindingdefinition[GO:0001851]  
1
  • UniProtKB
Enzyme bindingdefinition[GO:0019899]  
1
  • BHF-UCL
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
7
  • UniProtKB
  • IntAct
  • BHF-UCL
Proteinase activated receptor bindingdefinition[GO:0031871]  
1
  • UniProtKB
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981] silver  
1
  • Ortholog Compara
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • BHF-UCL
GO biological process 
Cellular response to interleukin-6definition[GO:0071354]  
1
  • BHF-UCL
DNA biosynthetic processdefinition[GO:0071897] silver  
1
  • Ortholog Compara
Histone deacetylationdefinition[GO:0016575]  
1
  • UniProtKB
Mitochondrion organizationdefinition[GO:0007005]  
1
  • UniProtKB
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766]  
2
  • BHF-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • BHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • BHF-UCL
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
1
  • UniProtKB
Negative regulation of glucocorticoid receptor signaling pathwaydefinition[GO:2000323]  
1
  • BHF-UCL
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • UniProtKB
Negative regulation of transcription by competitive promoter bindingdefinition[GO:0010944]  
1
  • BHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • BHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
3
  • BHF-UCL
  • UniProtKB
Osteoblast differentiationdefinition[GO:0001649]  
1
  • UniProtKB
Positive regulation of complement activationdefinition[GO:0045917]  
1
  • UniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • UniProtKB
Positive regulation of G-protein coupled receptor protein signaling pathwaydefinition[GO:0045745]  
1
  • UniProtKB
Positive regulation of protein stabilizationdefinition[GO:1903994]  
1
  • UniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Progesterone receptor signaling pathwaydefinition[GO:0050847]  
1
  • BHF-UCL
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • UniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
1
  • Ortholog Compara
 

Keywords

Biological process 
DNA synthesis  definition   [KW-0237]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Prohibitin
GenomeRNAi: 5245
PRO: PR:P35232