PHB - Prohibitin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
PHB »  Prohibitin
 
Gene name:  PHB
Family name: Prohibitin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 116 2
GENE REF ISO

Function

 show evidences
Overview 
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.  
1
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IPIBHF-UCL
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981] silver  
  • IEAOrtholog Compara
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
GO biological process 
Cellular response to interleukin-6definition[GO:0071354]  
1
  • IDABHF-UCL
DNA biosynthetic processdefinition[GO:0071897] silver  
  • IEAOrtholog Compara
DNA replicationdefinition[GO:0006260]  
  • IEAUniProtKB KW
Histone deacetylationdefinition[GO:0016575]  
1
  • IDAUniProtKB
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766]  
2
  • IMPBHF-UCL
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IMPBHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IMPBHF-UCL
Negative regulation of glucocorticoid receptor signaling pathwaydefinition[GO:2000323]  
1
  • IDABHF-UCL
Negative regulation of transcription by competitive promoter bindingdefinition[GO:0010944]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDABHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
3
  • IMPBHF-UCL
  • IDAUniProtKB
Osteoblast differentiationdefinition[GO:0001649]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Progesterone receptor signaling pathwaydefinition[GO:0050847]  
1
  • IDABHF-UCL
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • TASUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAUniProtKB
Signal transductiondefinition[GO:0007165]  
1
  • TASUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IEAOrtholog Compara
 

Keywords

Biological process 
DNA synthesis  definition   [KW-0237]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Prohibitin
GenomeRNAi: 5245
PRO: PR:P35232