NF2 - Merlin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
NF2 »  Merlin
 
Gene name:  NF2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 131 10
GENE REF ISO

Function

 show evidences
Overview 
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.  
2
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
17
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • IMPHGNC
Cell-cell junction organizationdefinition[GO:0045216] silver  
  • IEAOrtholog Compara
Ectoderm developmentdefinition[GO:0007398] silver  
  • IEAOrtholog Compara
Lens fiber cell differentiationdefinition[GO:0070306] silver  
  • IEAOrtholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • TASHGNC
Negative regulation of cell proliferationdefinition[GO:0008285]  
3
  • IDAUniProtKB
  • IMPHGNC
Negative regulation of cell-cell adhesiondefinition[GO:0022408]  
1
  • IDAHGNC
Negative regulation of cell-matrix adhesiondefinition[GO:0001953]  
1
  • TASHGNC
Negative regulation of DNA replicationdefinition[GO:0008156]  
1
  • IMPHGNC
Negative regulation of JAK-STAT cascadedefinition[GO:0046426]  
1
  • IDAHGNC
Negative regulation of MAPK cascadedefinition[GO:0043409] silver  
  • IEAOrtholog Compara
Negative regulation of protein kinase activitydefinition[GO:0006469] silver  
  • IEAOrtholog Compara
Negative regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042518]  
1
  • IDAHGNC
Negative regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042524]  
1
  • IDAHGNC
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • IMPHGNC
Regulation of hippo signalingdefinition[GO:0035330]  
1
  • IMPUniProtKB
Schwann cell proliferationdefinition[GO:0014010]  
1
  • IMPHGNC
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Merlin_(protein)
GenomeRNAi: 4771
PRO: PR:P35240