NF2 - Merlin - human protein (Function)
 
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NF2 »  Merlin
 
Protein also known as:  Moesin-ezrin-radixin-like protein.
Gene name:  NF2
Entry whose protein(s) existence is based on evidence at protein level
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1 136 10
GENE REF ISO

Function

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Overview 
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.  
3
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
17
  • IntAct
  • UniProtKB
  • HGNC
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • HGNC
Cell-cell junction organizationdefinition[GO:0045216] silver  
1
  • Ortholog Compara
Ectoderm developmentdefinition[GO:0007398] silver  
1
  • Ortholog Compara
Hippocampus developmentdefinition[GO:0021766] silver  
1
  • Ortholog Compara
Lens fiber cell differentiationdefinition[GO:0070306] silver  
1
  • Ortholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
1
  • Ortholog Compara
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • HGNC
Negative regulation of cell proliferationdefinition[GO:0008285]  
3
  • UniProtKB
  • HGNC
Negative regulation of cell-cell adhesiondefinition[GO:0022408]  
1
  • HGNC
Negative regulation of cell-matrix adhesiondefinition[GO:0001953]  
1
  • HGNC
Negative regulation of DNA replicationdefinition[GO:0008156]  
1
  • HGNC
Negative regulation of JAK-STAT cascadedefinition[GO:0046426]  
1
  • HGNC
Negative regulation of MAPK cascadedefinition[GO:0043409] silver  
1
  • Ortholog Compara
Negative regulation of protein kinase activitydefinition[GO:0006469] silver  
1
  • Ortholog Compara
Negative regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042518]  
1
  • HGNC
Negative regulation of tyrosine phosphorylation of Stat5 proteindefinition[GO:0042524]  
1
  • HGNC
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Positive regulation of cell differentiationdefinition[GO:0045597] silver  
1
  • Ortholog Compara
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • HGNC
Regulation of hippo signalingdefinition[GO:0035330]  
1
  • UniProtKB
Regulation of neural precursor cell proliferationdefinition[GO:2000177] silver  
1
  • Ortholog Compara
Regulation of protein localization to nucleusdefinition[GO:1900180] silver  
1
  • Ortholog Compara
Regulation of protein stabilitydefinition[GO:0031647] silver  
1
  • Ortholog Compara
Schwann cell proliferationdefinition[GO:0014010]  
1
  • HGNC
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Merlin_(protein)
GenomeRNAi: 4771
PRO: PR:P35240