GTF2F1 - General transcription factor IIF subunit 1 - human protein (Function)
 
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GTF2F1 »  General transcription factor IIF subunit 1
 
Protein also known as:  Transcription initiation factor IIF subunit alpha (TFIIF-alpha).
Gene name:  GTF2F1
Family name: TFIIF alpha subunit
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.  
1
  • CuratedUniProtKB
GO molecular function 
Catalytic activitydefinition[GO:0003824] silver  
  • IEAInterPro 2 GO
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Phosphatase activator activitydefinition[GO:0019211]  
1
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
GO biological process 
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAGOC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Basal transcription factors  hsa03022+2962  
According to Reactome, this protein belongs to the following pathways:
Abortive elongation of HIV-1 transcript in the absence of Tat  REACT_6261  
Formation of HIV elongation complex in the absence of HIV Tat  REACT_22201  
Formation of HIV-1 elongation complex containing HIV-1 Tat  REACT_6346  
Formation of the Early Elongation Complex  REACT_846  
Formation of the HIV-1 Early Elongation Complex  REACT_6319  
HIV elongation arrest and recovery  REACT_6259  
HIV Transcription Initiation  REACT_6332  
mRNA Capping  REACT_1470  
mRNA Splicing - Major Pathway  REACT_467  
mRNA Splicing - Minor Pathway  REACT_1753  
Pausing and recovery of HIV elongation  REACT_6244  
Pausing and recovery of Tat-mediated HIV elongation  REACT_6143  
Processing of Capped Intron-Containing Pre-mRNA  REACT_125  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_975  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_6237  
RNA Polymerase II HIV Promoter Escape  REACT_6253  
RNA Polymerase II Pre-transcription Events  REACT_22107  
RNA Polymerase II Promoter Escape  REACT_2089  
RNA Polymerase II Transcription Elongation  REACT_833  
RNA Polymerase II Transcription Initiation  REACT_1851  
RNA Polymerase II Transcription Initiation And Promoter Clearance  REACT_834  
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  REACT_1655  
Tat-mediated elongation of the HIV-1 transcript  REACT_6162  
Tat-mediated HIV elongation arrest and recovery  REACT_6344  
Transcription of the HIV genome  REACT_6233  
Viral Messenger RNA Synthesis  REACT_6354  
Caution 
Was reported (PubMed10428810) to have a protein kinase activity and to autophosphorylates on Ser-385 and Thr-389.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GTF2F1
GenomeRNAi: 2962
PRO: PR:P35269