GTF2F1 - General transcription factor IIF subunit 1 - human protein (Function)
 
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GTF2F1 »  General transcription factor IIF subunit 1
 
Protein also known as:  Transcription initiation factor IIF subunit alpha (TFIIF-alpha).
Gene name:  GTF2F1
Family name: TFIIF alpha subunit
Entry whose protein(s) existence is based on evidence at protein level
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1 59 1
GENE REF ISO

Function

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Overview 
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.  
1
  • CuratedUniProtKB
GO molecular function 
Catalytic activitydefinition[GO:0003824] silver  
  • IEAInterPro 2 GO
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Phosphatase activator activitydefinition[GO:0019211]  
1
  • IDAUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Transcription coactivator activitydefinition[GO:0003713]  
1
  • TASPINC
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIBHF-UCL
GO biological process 
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IDAGOC
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Response to virusdefinition[GO:0009615]  
1
  • IEPUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Basal transcription factors  hsa03022+2962  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Elongation arrest and recovery  REACT_1892  
Gene Expression  REACT_71  
Transcription  REACT_1788  
Caution 
Was reported (PubMed10428810) to have a protein kinase activity and to autophosphorylates on Ser-385 and Thr-389.  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: GTF2F1
GenomeRNAi: 2962
PRO: PR:P35269