SPR - Sepiapterin reductase - human protein (Function)
 
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Protein
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SPR »  Sepiapterin reductase
 
Gene name:  SPR
Family name: Sepiapterin reductase
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.  
  • CuratedUniProtKB
GO molecular function 
Aldo-keto reductase (NADP) activitydefinition[GO:0004033]  
1
  • TASUniProtKB
NADP bindingdefinition[GO:0050661]  
1
  • TASUniProtKB
Sepiapterin reductase activitydefinition[GO:0004757]  
  • ISSOrtholog Curator
GO biological process 
Nitric oxide biosynthetic processdefinition[GO:0006809]  
1
  • IDAUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • TASUniProtKB
Tetrahydrobiopterin biosynthetic processdefinition[GO:0006729]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
L-erythro-7,8-dihydrobiopterin + NADP(+) sepiapterin + NADPH.  
  • CuratedUniProtKB
L-erythro-tetrahydrobiopterin + 2 NADP(+) 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Folate biosynthesis  hsa00790+6697  
Metabolic pathways  hsa01100+6697  
According to Reactome, this protein belongs to the following pathway:
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation  REACT_111176  
 
More information is available from:
 

Biophysicochemical properties

Kinetic parameters
KM 10 uM for NADPH
KM 14.3 uM for sepiapterin

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Sepiapterin_reductase
GenomeRNAi: 6697
PRO: PR:P35270