ADM - ADM - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ADM »  ADM
 
Cleaved into:  Adrenomedullin; Proadrenomedullin N-20 terminal peptide.
Gene name:  ADM
Family name: Adrenomedullin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 235 1
GENE REF ISO

Function

 show evidences
Overview 
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.  
1
  • UniProtKB
GO molecular function 
Adrenomedullin receptor bindingdefinition[GO:0031700] silver  
1
  • Ortholog Compara
Hormone activitydefinition[GO:0005179]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Receptor bindingdefinition[GO:0005102]  
2
  • PINC
GO biological process 
Agingdefinition[GO:0007568] silver  
1
  • Ortholog Compara
Androgen metabolic processdefinition[GO:0008209] silver  
1
  • Ortholog Compara
Blood circulationdefinition[GO:0008015]  
1
  • PINC
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670] silver  
1
  • Ortholog Compara
cAMP biosynthetic processdefinition[GO:0006171]  
1
  • UniProtKB
cAMP-mediated signalingdefinition[GO:0019933] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Developmental growthdefinition[GO:0048589] silver  
1
  • Ortholog Compara
Female pregnancydefinition[GO:0007565] silver  
1
  • Ortholog Compara
G-protein coupled receptor internalizationdefinition[GO:0002031]  
1
  • UniProtKB
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Hormone secretiondefinition[GO:0046879] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Negative regulation of vascular permeabilitydefinition[GO:0043116] silver  
1
  • Ortholog Compara
Negative regulation of vasoconstrictiondefinition[GO:0045906]  
1
  • BHF-UCL
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Neuron projection regenerationdefinition[GO:0031102] silver  
1
  • Ortholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
1
  • Ortholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
1
  • Ortholog Compara
Positive regulation of heart ratedefinition[GO:0010460] silver  
1
  • Ortholog Compara
Positive regulation of vasculogenesisdefinition[GO:2001214] silver  
1
  • Ortholog Compara
Positive regulation of vasodilationdefinition[GO:0045909] silver  
1
  • Ortholog Compara
Progesterone biosynthetic processdefinition[GO:0006701]  
1
  • PINC
Receptor internalizationdefinition[GO:0031623]  
3
  • UniProtKB
Regulation of the force of heart contractiondefinition[GO:0002026] silver  
1
  • Ortholog Compara
Response to colddefinition[GO:0009409] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to insulindefinition[GO:0032868] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Response to starvationdefinition[GO:0042594] silver  
1
  • Ortholog Compara
Response to woundingdefinition[GO:0009611] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Spongiotrophoblast layer developmentdefinition[GO:0060712] silver  
1
  • Ortholog Compara
Vascular smooth muscle cell developmentdefinition[GO:0097084] silver  
1
  • Ortholog Compara
Vasculogenesisdefinition[GO:0001570]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Calcitonin-like ligand receptors  REACT_18290  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Adrenomedullin
GenomeRNAi: 133
PRO: PR:P35318