ADM - ADM - human protein (Function)
 
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Protein
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ADM »  ADM
 
Cleaved into:  Adrenomedullin; Proadrenomedullin N-20 terminal peptide.
Gene name:  ADM
Family name: Adrenomedullin
Entry whose protein(s) existence is based on evidence at protein level
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1 211 1
GENE REF ISO

Function

 show evidences
Overview 
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.  
  • CuratedUniProtKB
GO molecular function 
Adrenomedullin receptor bindingdefinition[GO:0031700] silver  
  • IEAOrtholog Compara
Hormone activitydefinition[GO:0005179]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor bindingdefinition[GO:0005102]  
2
  • TASPINC
GO biological process 
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Androgen metabolic processdefinition[GO:0008209] silver  
  • IEAOrtholog Compara
Blood circulationdefinition[GO:0008015]  
1
  • TASPINC
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670] silver  
  • IEAOrtholog Compara
cAMP biosynthetic processdefinition[GO:0006171]  
1
  • IDAUniProtKB
cAMP-mediated signalingdefinition[GO:0019933] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Developmental growthdefinition[GO:0048589] silver  
  • IEAOrtholog Compara
Female pregnancydefinition[GO:0007565] silver  
  • IEAOrtholog Compara
G-protein coupled receptor internalizationdefinition[GO:0002031]  
1
  • IDAUniProtKB
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Hormone secretiondefinition[GO:0046879] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of vascular permeabilitydefinition[GO:0043116] silver  
  • IEAOrtholog Compara
Negative regulation of vasoconstrictiondefinition[GO:0045906]  
1
  • IDABHF-UCL
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Neuron projection regenerationdefinition[GO:0031102] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
1
  • IDAUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
  • IEAOrtholog Compara
Positive regulation of heart ratedefinition[GO:0010460] silver  
  • IEAOrtholog Compara
Positive regulation of vasculogenesisdefinition[GO:2001214] silver  
  • IEAOrtholog Compara
Positive regulation of vasodilationdefinition[GO:0045909] silver  
  • IEAOrtholog Compara
Progesterone biosynthetic processdefinition[GO:0006701]  
1
  • TASPINC
Receptor internalizationdefinition[GO:0031623]  
3
  • IDAUniProtKB
Regulation of the force of heart contractiondefinition[GO:0002026] silver  
  • IEAOrtholog Compara
Response to colddefinition[GO:0009409] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Spongiotrophoblast layer developmentdefinition[GO:0060712] silver  
  • IEAOrtholog Compara
Vascular smooth muscle cell developmentdefinition[GO:0097084] silver  
  • IEAOrtholog Compara
Vasculogenesisdefinition[GO:0001570]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Adrenomedullin
GenomeRNAi: 133
PRO: PR:P35318