ADRA1A - Alpha-1A adrenergic receptor - human protein (Function)
 
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ADRA1A »  Alpha-1A adrenergic receptor
 
Protein also known as:  Alpha-1C adrenergic receptor.
Gene name:  ADRA1A
Entry whose protein(s) existence is based on evidence at protein level
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1 79 9
GENE REF ISO

Function

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Overview 
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.  
2
  • CuratedUniProtKB
GO molecular function 
Alpha1-adrenergic receptor activitydefinition[GO:0004937]  
2
  • NASUniProtKB
  • ISSOrtholog Curator
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAUniProtKB
GO biological process 
Activation of phospholipase C activitydefinition[GO:0007202]  
  • ISSOrtholog Curator
Adrenergic receptor signaling pathwaydefinition[GO:0071875]  
3
  • TASGOC
  • IEAInterPro 2 GO
  • ISSOrtholog Curator
  • IEAOrtholog Compara
Adult heart developmentdefinition[GO:0007512] silver  
  • IEAOrtholog Compara
Agingdefinition[GO:0007568]  
  • ISSOrtholog Curator
Apoptotic processdefinition[GO:0006915]  
1
  • TASPINC
Calcium ion transport into cytosoldefinition[GO:0060402]  
  • ISSOrtholog Curator
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASPINC
Micturitiondefinition[GO:0060073] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressuredefinition[GO:0001985] silver  
  • IEAOrtholog Compara
Negative regulation of Rho protein signal transductiondefinition[GO:0035024]  
  • ISSOrtholog Curator
Negative regulation of synaptic transmission, GABAergicdefinition[GO:0032229]  
  • ISSOrtholog Curator
Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressuredefinition[GO:0001994] silver  
  • IEAOrtholog Compara
Organ growthdefinition[GO:0035265] silver  
  • IEAOrtholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200] silver  
  • IEAOrtholog Compara
Pilomotor reflexdefinition[GO:0097195] silver  
  • IEAOrtholog Compara
Positive regulation of action potentialdefinition[GO:0045760]  
  • ISSOrtholog Curator
Positive regulation of cardiac muscle contractiondefinition[GO:0060452]  
  • ISSOrtholog Curator
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
  • ISSOrtholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
  • ISSOrtholog Curator
Positive regulation of heart rate by epinephrine-norepinephrinedefinition[GO:0001996] silver  
  • IEAOrtholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDAUniProtKB
Positive regulation of protein kinase C signalingdefinition[GO:0090037]  
  • ISSOrtholog Curator
Positive regulation of smooth muscle contractiondefinition[GO:0045987] silver  
  • IEAOrtholog Compara
Positive regulation of systemic arterial blood pressuredefinition[GO:0003084] silver  
  • IEAOrtholog Compara
Positive regulation of the force of heart contraction by epinephrine-norepinephrinedefinition[GO:0001997] silver  
  • IEAOrtholog Compara
Positive regulation of vasoconstrictiondefinition[GO:0045907]  
  • ISSOrtholog Curator
Response to drugdefinition[GO:0042493]  
  • ISSOrtholog Curator
Response to hormonedefinition[GO:0009725]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Smooth muscle contractiondefinition[GO:0006939]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+148  
Neuroactive ligand-receptor interaction  hsa04080+148  
Salivary secretion  hsa04970+148  
Vascular smooth muscle contraction  hsa04270+148  
According to Reactome, this protein belongs to the following pathways:
Adrenoceptors  REACT_16927  
G alpha (12/13) signalling events  REACT_18407  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Alpha-1A_adrenergic_receptor
GenomeRNAi: 148
PRO: PR:P35348
Chemistry
GuidetoPHARMACOLOGY: 22