HRH1 - Histamine H1 receptor - human protein (Function)
 
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HRH1 »  Histamine H1 receptor  (H1R)
 
Gene name:  HRH1
Entry whose protein(s) existence is based on evidence at protein level
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1 82 1
GENE REF ISO

Function

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Overview 
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.  
1
  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • PINC
Histamine bindingdefinition[GO:0051381]  
1
  • RefGenome
Histamine receptor activitydefinition[GO:0004969]  
1
  • Ortholog Curator
GO biological process 
Cellular response to histaminedefinition[GO:0071420]  
1
  • Ortholog Curator
Eosinophil chemotaxisdefinition[GO:0048245] silver  
1
  • InterPro 2 GO
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • Ortholog Curator
Inflammatory responsedefinition[GO:0006954]  
1
  • PINC
Inositol phosphate-mediated signalingdefinition[GO:0048016]  
1
  • Ortholog Curator
Memorydefinition[GO:0007613] silver  
1
  • Ortholog Compara
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • PINC
Not  Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • RefGenome
Positive regulation of inositol trisphosphate biosynthetic processdefinition[GO:0032962]  
1
  • Ortholog Curator
Positive regulation of vasoconstrictiondefinition[GO:0045907] silver  
1
  • InterPro 2 GO
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
1
  • Ortholog Compara
Regulation of synaptic transmissiondefinition[GO:0050804]  
1
  • RefGenome
Regulation of vascular permeabilitydefinition[GO:0043114] silver  
1
  • InterPro 2 GO
Regulation of vasoconstrictiondefinition[GO:0019229]  
1
  • RefGenome
Sensory perception of chemical stimulusdefinition[GO:0007606]  
1
  • RefGenome
Visual learningdefinition[GO:0008542] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+3269  
Neuroactive ligand-receptor interaction  hsa04080+3269  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Histamine receptors  REACT_16903  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Histamine_H1_receptor
GenomeRNAi: 3269
PRO: PR:P35367
Chemistry
GuidetoPHARMACOLOGY: 262