ADRA1B - Alpha-1B adrenergic receptor - human protein (Function)
 
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ADRA1B »  Alpha-1B adrenergic receptor
 
Protein also known as:  Alpha-1B adrenoreceptor (Alpha-1B adrenoceptor).
Gene name:  ADRA1B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.  
2
  • CuratedUniProtKB
GO molecular function 
Alpha1-adrenergic receptor activitydefinition[GO:0004937] silver  
  • IEAOrtholog Compara
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAUniProtKB
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASPINC
Adrenergic receptor signaling pathwaydefinition[GO:0071875]  
1
  • TASGOC
  • IEAOrtholog Compara
  • IEAInterPro 2 GO
Adult heart developmentdefinition[GO:0007512] silver  
  • IEAOrtholog Compara
Behavioral response to cocainedefinition[GO:0048148] silver  
  • IEAOrtholog Compara
Blood vessel remodelingdefinition[GO:0001974] silver  
  • IEAOrtholog Compara
Cell growthdefinition[GO:0016049] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Glucose homeostasisdefinition[GO:0042593] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASPINC
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Negative regulation of glycogen catabolic processdefinition[GO:0045818] silver  
  • IEAOrtholog Compara
Organ growthdefinition[GO:0035265] silver  
  • IEAOrtholog Compara
Positive regulation of glycogen catabolic processdefinition[GO:0045819] silver  
  • IEAOrtholog Compara
Positive regulation of heart rate by epinephrine-norepinephrinedefinition[GO:0001996] silver  
  • IEAOrtholog Compara
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IDAUniProtKB
Positive regulation of the force of heart contraction by epinephrine-norepinephrinedefinition[GO:0001997] silver  
  • IEAOrtholog Compara
Regulation of cardiac muscle contractiondefinition[GO:0055117] silver  
  • IEAInterPro 2 GO
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
  • IEAInterPro 2 GO
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to morphinedefinition[GO:0043278] silver  
  • IEAOrtholog Compara
Vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressuredefinition[GO:0001987] silver  
  • IEAOrtholog Compara
Visual learningdefinition[GO:0008542] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+147  
Neuroactive ligand-receptor interaction  hsa04080+147  
Salivary secretion  hsa04970+147  
Vascular smooth muscle contraction  hsa04270+147  
According to Reactome, this protein belongs to the following pathways:
Adrenoceptors  REACT_16927  
G alpha (12/13) signalling events  REACT_18407  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Alpha-1B_adrenergic_receptor
GenomeRNAi: 147
PRO: PR:P35368
Chemistry
GuidetoPHARMACOLOGY: 23