THBS4 - Thrombospondin-4 - human protein (Function)
 
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THBS4 »  Thrombospondin-4
 
Gene name:  THBS4
Family name: Thrombospondin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).  
1
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
2
  • IDAUniProtKB
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Heparin bindingdefinition[GO:0008201]  
1
  • IDAUniProtKB
Integrin bindingdefinition[GO:0005178]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Behavioral response to paindefinition[GO:0048266]  
  • ISSOrtholog Curator
Endothelial cell-cell adhesiondefinition[GO:0071603]  
1
  • IDAUniProtKB
Myoblast migrationdefinition[GO:0051451]  
1
  • IDAUniProtKB
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • IEPUniProtKB
Positive regulation of cell divisiondefinition[GO:0051781]  
  • IEAUniProtKB KW
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IDAUniProtKB
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023]  
1
  • IDAUniProtKB
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
1
  • IDAUniProtKB
Regulation of tissue remodelingdefinition[GO:0034103]  
  • ISSOrtholog Curator
Response to endoplasmic reticulum stressdefinition[GO:0034976]  
  • ISSOrtholog Curator
Response to unfolded proteindefinition[GO:0006986]  
  • IEAUniProtKB KW
Tissue remodelingdefinition[GO:0048771]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathways:
ECM-receptor interaction  hsa04512+7060  
Focal adhesion  hsa04510+7060  
Malaria  hsa05144+7060  
Phagosome  hsa04145+7060  
TGF-beta signaling pathway  hsa04350+7060  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Tissue remodeling  definition   [KW-0797]
Unfolded protein response  definition   [KW-0834]
Molecular function 
Growth factor  definition   [KW-0339]
Mitogen  definition   [KW-0497]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: THBS4
GenomeRNAi: 7060
PRO: PR:P35443