DRD3 - D(3) dopamine receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
DRD3 »  D(3) dopamine receptor
 
Protein also known as:  Dopamine D3 receptor.
Gene name:  DRD3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 81 2
GENE REF ISO

Function

 show evidences
Overview 
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.  
1
  • CuratedUniProtKB
GO molecular function 
D1 dopamine receptor bindingdefinition[GO:0031748] silver  
  • IEAOrtholog Compara
Dopamine bindingdefinition[GO:0035240] silver  
  • IEAOrtholog Compara
Dopamine neurotransmitter receptor activity, coupled via Gi/Godefinition[GO:0001591]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Drug bindingdefinition[GO:0008144]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IPIBHF-UCL
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
GO biological process 
Acid secretiondefinition[GO:0046717]  
  • ISSOrtholog Curator
Adenylate cyclase-activating dopamine receptor signaling pathwaydefinition[GO:0007191]  
1
  • IDABHF-UCL
Adenylate cyclase-inhibiting dopamine receptor signaling pathwaydefinition[GO:0007195]  
2
  • IDABHF-UCL
Arachidonic acid secretiondefinition[GO:0050482]  
1
  • IDABHF-UCL
Behavioral response to cocainedefinition[GO:0048148]  
1
  • IEPBHF-UCL
  • ISSOrtholog Curator
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • IDABHF-UCL
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Dopamine metabolic processdefinition[GO:0042417]  
1
  • ICBHF-UCL
G-protein coupled receptor internalizationdefinition[GO:0002031]  
1
  • IDABHF-UCL
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDABHF-UCL
Gastric emptyingdefinition[GO:0035483] silver  
  • IEAOrtholog Compara
Learningdefinition[GO:0007612]  
1
  • NASBHF-UCL
Learning or memorydefinition[GO:0007611]  
1
  • NASBHF-UCL
Locomotory behaviordefinition[GO:0007626]  
  • ISSOrtholog Curator
Musculoskeletal movement, spinal reflex actiondefinition[GO:0050883]  
  • ISSOrtholog Curator
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • IDABHF-UCL
Negative regulation of blood pressuredefinition[GO:0045776]  
  • ISSOrtholog Curator
Negative regulation of dopamine receptor signaling pathwaydefinition[GO:0060160] silver  
  • IEAOrtholog Compara
Negative regulation of oligodendrocyte differentiationdefinition[GO:0048715]  
  • ISSOrtholog Curator
Negative regulation of protein kinase B signalingdefinition[GO:0051898]  
  • ISSOrtholog Curator
Negative regulation of protein secretiondefinition[GO:0050709]  
1
  • IDABHF-UCL
Negative regulation of sodium:proton antiporter activitydefinition[GO:0032416] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cytokinesisdefinition[GO:0032467]  
1
  • IMPUniProtKB
Positive regulation of dopamine receptor signaling pathwaydefinition[GO:0060161]  
  • ISSOrtholog Curator
Positive regulation of mitosisdefinition[GO:0045840]  
  • ISSOrtholog Curator
Positive regulation of renal sodium excretiondefinition[GO:0035815] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Prepulse inhibitiondefinition[GO:0060134]  
1
  • IMPBHF-UCL
Regulation of blood volume by renin-angiotensindefinition[GO:0002016] silver  
  • IEAOrtholog Compara
Regulation of cAMP metabolic processdefinition[GO:0030814]  
1
  • IDABHF-UCL
Regulation of circadian sleep/wake cycle, sleepdefinition[GO:0045187] silver  
  • IEAOrtholog Compara
Regulation of dopamine secretiondefinition[GO:0014059]  
  • ISSOrtholog Curator
Regulation of dopamine uptake involved in synaptic transmissiondefinition[GO:0051584]  
1
  • ICBHF-UCL
Regulation of lipid metabolic processdefinition[GO:0019216] silver  
  • IEAOrtholog Compara
Regulation of locomotion involved in locomotory behaviordefinition[GO:0090325] silver  
  • IEAOrtholog Compara
Regulation of multicellular organism growthdefinition[GO:0040014] silver  
  • IEAOrtholog Compara
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to cocainedefinition[GO:0042220]  
1
  • IEPBHF-UCL
Response to drugdefinition[GO:0042493]  
  • ISSOrtholog Curator
Not  Response to ethanoldefinition[GO:0045471]  
  • ISSOrtholog Curator
Response to histaminedefinition[GO:0034776]  
1
  • IDABHF-UCL
Response to morphinedefinition[GO:0043278]  
  • ISSOrtholog Curator
Social behaviordefinition[GO:0035176]  
1
  • NASBHF-UCL
Synaptic transmission, dopaminergicdefinition[GO:0001963] silver  
  • IEAOrtholog Compara
Visual learningdefinition[GO:0008542]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+1814  
Neuroactive ligand-receptor interaction  hsa04080+1814  
According to Reactome, this protein belongs to the following pathways:
Dopamine receptors  REACT_16968  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
PRO: PR:P35462
Chemistry
GuidetoPHARMACOLOGY: 216