SCN1A - Sodium channel protein type 1 subunit alpha - human protein (Function)
 
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Protein
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SCN1A »  Sodium channel protein type 1 subunit alpha
 
Protein also known as:  Voltage-gated sodium channel subunit alpha Nav1.1.
Gene name:  SCN1A
Entry whose protein(s) existence is based on evidence at protein level
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1 216 3
GENE REF ISO

Function

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Overview 
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.10.7  
GO molecular function 
Voltage-gated sodium channel activitydefinition[GO:0005248]  
1
  • NASUniProtKB
GO biological process 
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Neuromuscular process controlling posturedefinition[GO:0050884] silver  
  • IEAOrtholog Compara
Neuronal action potentialdefinition[GO:0019228] silver  
  • IBARefGenome
Neuronal action potential propagationdefinition[GO:0019227] silver  
  • IEAOrtholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • NASGOC
  • IEAOrtholog Compara
  • IEAInterPro 2 GO
  • IEAUniProtKB KW
Sodium ion transportdefinition[GO:0006814]  
1
  • NASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Dopaminergic synapse  hsa04728+6323  
According to Reactome, this protein belongs to the following pathway:
Interaction between L1 and Ankyrins  REACT_22266  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Nav1.1
GenomeRNAi: 6323
PRO: PR:P35498
Chemistry
GuidetoPHARMACOLOGY: 578