SCN4A - Sodium channel protein type 4 subunit alpha - human protein (Function)
 
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Protein
Gene
References

 
SCN4A »  Sodium channel protein type 4 subunit alpha
 
Gene name:  SCN4A
Entry whose protein(s) existence is based on evidence at protein level
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1 103 1
GENE REF ISO

Function

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Overview 
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. This sodium channel may be present in both denervated and innervated skeletal muscle.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.10.4  
GO molecular function 
Voltage-gated sodium channel activitydefinition[GO:0005248] silver  
  • IBARefGenome
GO biological process 
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Neuronal action potentialdefinition[GO:0019228] silver  
  • IBARefGenome
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Sodium ion transmembrane transportdefinition[GO:0035725] silver  
  • IBARefGenome
Sodium ion transportdefinition[GO:0006814]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Interaction between L1 and Ankyrins  REACT_22266  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Nav1.4
GenomeRNAi: 6329
PRO: PR:P35499
Chemistry
GuidetoPHARMACOLOGY: 581