CLCN1 - Chloride channel protein 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CLCN1 »  Chloride channel protein 1  (ClC-1)
 
Protein also known as:  Chloride channel protein, skeletal muscle.
Gene name:  CLCN1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 99 1
GENE REF ISO

Function

 show evidences
Overview 
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the chloride carrier/channel (clc) family  2.A.49.2.1  
GO molecular function 
Adenyl nucleotide bindingdefinition[GO:0030554] silver  
  • IEAInterPro 2 GO
Chloride channel activitydefinition[GO:0005254]  
1
  • TASPINC
Voltage-gated chloride channel activitydefinition[GO:0005247] silver  
  • IEAInterPro 2 GO
GO biological process 
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • TASGOC
  • IEAUniProtKB KW
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Neuronal action potential propagationdefinition[GO:0019227] silver  
  • IEAOrtholog Compara
Regulation of anion transportdefinition[GO:0044070]  
1
  • TASGOC
  • IEAInterPro 2 GO
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
Note 
The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CLCN1
GenomeRNAi: 1180
PRO: PR:P35523
Chemistry
GuidetoPHARMACOLOGY: 698