MSX2 - Homeobox protein MSX-2 - human protein (Function)
 
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MSX2 »  Homeobox protein MSX-2
 
Protein also known as:  Homeobox protein Hox-8.
Gene name:  MSX2
Family name: Msh homeobox
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
  • IEAOrtholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activitydefinition[GO:0000982] silver  
  • IEAOrtholog Compara
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAMGI
Transcription cofactor activitydefinition[GO:0003712]  
  • ISSOrtholog Curator
Transcription factor bindingdefinition[GO:0008134] silver  
  • IEAOrtholog Compara
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
  • ISSOrtholog Curator
GO biological process 
Activation of meiosisdefinition[GO:0090427] silver  
  • IEAOrtholog Compara
Anagendefinition[GO:0042640] silver  
  • IEAOrtholog Compara
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
BMP signaling pathway involved in heart developmentdefinition[GO:0061312] silver  
  • IEAOrtholog Compara
Bone trabecula formationdefinition[GO:0060346] silver  
  • IEAOrtholog Compara
Branching involved in mammary gland duct morphogenesisdefinition[GO:0060444] silver  
  • IEAOrtholog Compara
Cellular response to estradiol stimulusdefinition[GO:0071392] silver  
  • IEAOrtholog Compara
Cellular response to growth factor stimulusdefinition[GO:0071363] silver  
  • IEAOrtholog Compara
Chondrocyte developmentdefinition[GO:0002063] silver  
  • IEAOrtholog Compara
Cranial suture morphogenesisdefinition[GO:0060363]  
1
  • TASBHF-UCL
Embryonic forelimb morphogenesisdefinition[GO:0035115] silver  
  • IEAOrtholog Compara
Embryonic hindlimb morphogenesisdefinition[GO:0035116] silver  
  • IEAOrtholog Compara
Embryonic nail plate morphogenesisdefinition[GO:0035880] silver  
  • IEAOrtholog Compara
Enamel mineralizationdefinition[GO:0070166] silver  
  • IEAOrtholog Compara
Endochondral bone growthdefinition[GO:0003416] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198] silver  
  • IEAOrtholog Compara
Frontal suture morphogenesisdefinition[GO:0060364] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of CREB transcription factor activitydefinition[GO:0032792] silver  
  • IEAOrtholog Compara
Negative regulation of fat cell differentiationdefinition[GO:0045599] silver  
  • IEAOrtholog Compara
Negative regulation of keratinocyte differentiationdefinition[GO:0045617] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Negative regulation of transcription regulatory region DNA bindingdefinition[GO:2000678]  
  • ISSOrtholog Curator
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Osteoblast developmentdefinition[GO:0002076] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
  • ISSOrtholog Curator
Outflow tract septum morphogenesisdefinition[GO:0003148] silver  
  • IEAOrtholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513] silver  
  • IEAOrtholog Compara
Positive regulation of catagendefinition[GO:0051795] silver  
  • IEAOrtholog Compara
Positive regulation of mesenchymal cell apoptotic processdefinition[GO:2001055] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
  • IEAOrtholog Compara
Transcription from RNA polymerase II promoterdefinition[GO:0006366] silver  
  • IEAOrtholog Compara
Wound healing, spreading of epidermal cellsdefinition[GO:0035313] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
HTLV-I infection  hsa05166+4488  
 

Keywords

Biological process 
Osteogenesis  definition   [KW-0892]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Msh_homeobox_2
GenomeRNAi: 4488
PRO: PR:P35548