PCK1 - Phosphoenolpyruvate carboxykinase, cytosolic [GTP] - human protein (Function)
 
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PCK1 »  Phosphoenolpyruvate carboxykinase, cytosolic [GTP]   [ EC 4.1.1.32 ]  (PEPCK-C)
 
Gene name:  PCK1
Entry whose protein(s) existence is based on evidence at protein level
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1 49 1
GENE REF ISO

Function

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Overview 
Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.  
  • CuratedUniProtKB
GO molecular function 
Carboxylic acid bindingdefinition[GO:0031406]  
1
  • IDABHF-UCL
GDP bindingdefinition[GO:0019003] silver  
  • IEAOrtholog Compara
GTP bindingdefinition[GO:0005525]  
1
  • IDABHF-UCL
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDABHF-UCL
Manganese ion bindingdefinition[GO:0030145]  
1
  • IDABHF-UCL
Phosphoenolpyruvate carboxykinase (GTP) activitydefinition[GO:0004613]  
  • ISSOrtholog Curator
GO biological process 
Gluconeogenesisdefinition[GO:0006094]  
  • ISSOrtholog Curator
  • IEAUniPathway
Glucose homeostasisdefinition[GO:0042593]  
  • ISSOrtholog Curator
Glucose metabolic processdefinition[GO:0006006]  
1
  • IMPBHF-UCL
Glycerol biosynthetic process from pyruvatedefinition[GO:0046327]  
  • ISSOrtholog Curator
Internal protein amino acid acetylationdefinition[GO:0006475]  
1
  • IDAUniProtKB
Oxaloacetate metabolic processdefinition[GO:0006107] silver  
  • IEAOrtholog Compara
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.1.1.32: GTP + oxaloacetate GDP + phosphoenolpyruvate + CO(2).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 manganese ion per subunit.  
1
  • CuratedUniProtKB
It is regulated in the following manner
Enzyme activity is enhanced by acetylation.  
1
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+5105  
Citrate cycle (TCA cycle)  hsa00020+5105  
Glycolysis / Gluconeogenesis  hsa00010+5105  
Insulin signaling pathway  hsa04910+5105  
Metabolic pathways  hsa01100+5105  
PPAR signaling pathway  hsa03320+5105  
Proximal tubule bicarbonate reclamation  hsa04964+5105  
Pyruvate metabolism  hsa00620+5105  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
Note 
In eukaryotes there are two isozymes: a cytoplasmic one and a mitochondrial one.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Gluconeogenesis  definition   [KW-0312]
Molecular function 
Decarboxylase  definition   [KW-0210]
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P35558
Other
GeneWiki: PCK1
GenomeRNAi: 5105
PRO: PR:P35558