IRS1 - Insulin receptor substrate 1 - human protein (Function)
 
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IRS1 »  Insulin receptor substrate 1  (IRS-1)
 
Gene name:  IRS1
Entry whose protein(s) existence is based on evidence at protein level
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1 324 1
GENE REF ISO

Function

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Overview 
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
Insulin receptor bindingdefinition[GO:0005158]  
2
  • IPIBHF-UCL
  • IPIUniProtKB
Insulin-like growth factor receptor bindingdefinition[GO:0005159]  
1
  • IPIUniProtKB
Phosphatidylinositol 3-kinase bindingdefinition[GO:0043548]  
2
  • IPIUniProtKB
  • IPIBHF-UCL
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
21
  • IPIIntAct
  • IPIUniProtKB
Protein kinase C bindingdefinition[GO:0005080]  
  • ISSOrtholog Curator
SH2 domain bindingdefinition[GO:0042169]  
  • ISSOrtholog Curator
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
Transmembrane receptor protein tyrosine kinase adaptor activitydefinition[GO:0005068]  
  • ISSOrtholog Curator
GO biological process 
Cellular response to insulin stimulusdefinition[GO:0032869]  
1
  • IMPBHF-UCL
Glucose homeostasisdefinition[GO:0042593]  
1
  • TASBHF-UCL
Insulin receptor signaling pathwaydefinition[GO:0008286]  
4
  • IMPBHF-UCL
  • IPIUniProtKB
Insulin-like growth factor receptor signaling pathwaydefinition[GO:0048009]  
1
  • IPIUniProtKB
Lipid catabolic processdefinition[GO:0016042] silver  
  • IEAOrtholog Compara
Mammary gland developmentdefinition[GO:0030879] silver  
  • IEAOrtholog Compara
Negative regulation of insulin receptor signaling pathwaydefinition[GO:0046627]  
  • ISSOrtholog Curator
Negative regulation of insulin secretiondefinition[GO:0046676]  
1
  • IDABHF-UCL
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • NASBHF-UCL
Positive regulation of fatty acid beta-oxidationdefinition[GO:0032000]  
1
  • IMPBHF-UCL
Positive regulation of glucose importdefinition[GO:0046326]  
1
  • IMPBHF-UCL
Positive regulation of glucose import in response to insulin stimulusdefinition[GO:2001275]  
1
  • IDABHF-UCL
Positive regulation of glucose metabolic processdefinition[GO:0010907]  
1
  • IMPBHF-UCL
Positive regulation of glycogen biosynthetic processdefinition[GO:0045725]  
2
  • NASBHF-UCL
Positive regulation of insulin receptor signaling pathwaydefinition[GO:0046628]  
  • ISSOrtholog Curator
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
  • ISSOrtholog Curator
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Protein localization to nucleusdefinition[GO:0034504] silver  
  • IEAOrtholog Compara
Regulation of gene expressiondefinition[GO:0010468] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868]  
1
  • IDABHF-UCL
Response to peptide hormonedefinition[GO:0043434]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+3667  
Aldosterone-regulated sodium reabsorption  hsa04960+3667  
Insulin signaling pathway  hsa04910+3667  
Neurotrophin signaling pathway  hsa04722+3667  
Type II diabetes mellitus  hsa04930+3667  
According to Reactome, this protein belongs to the following pathways:
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
Growth hormone receptor signaling  REACT_111133  
IRS activation  REACT_570  
IRS-related events triggered by IGF1R  REACT_150203  
PI3K Cascade  REACT_976  
PI3K/AKT activation  REACT_12464  
PIP3 activates AKT signaling  REACT_75829  
Signal attenuation  REACT_508  
Signaling by Leptin  REACT_169118  
SOS-mediated signalling  REACT_524  
 

Keywords

Molecular function 
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IRS1
GenomeRNAi: 3667
PRO: PR:P35568