AGL - Glycogen debranching enzyme - human protein (Function)
 
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AGL »  Glycogen debranching enzyme
 
Protein also known as:  Glycogen debrancher.
Gene name:  AGL
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.  
  • CuratedUniProtKB
GO molecular function 
4-alpha-glucanotransferase activitydefinition[GO:0004134] silver  
  • IBARefGenome
Amylo-alpha-1,6-glucosidase activitydefinition[GO:0004135] silver  
  • IBARefGenome
Glycogen debranching enzyme activitydefinition[GO:0004133]  
1
  • TASPINC
Polysaccharide bindingdefinition[GO:0030247] silver  
  • IEAOrtholog Compara
Polyubiquitin bindingdefinition[GO:0031593] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Glycogen biosynthetic processdefinition[GO:0005978]  
  • IEAUniProtKB KW
Glycogen catabolic processdefinition[GO:0005980] silver  
  • IBARefGenome
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.4.1.25: Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.  
  • CuratedUniProtKB
EC 3.2.1.33: Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.  
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycoside Hydrolase Family 13  GH13  
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+178  
Starch and sucrose metabolism  hsa00500+178  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Glycogen biosynthesis  definition   [KW-0320]
Molecular function 
Glycosidase  definition   [KW-0326]
Glycosyltransferase  definition   [KW-0328]
Hydrolase  definition   [KW-0378]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Glycogen_debranching_enzyme
GenomeRNAi: 178
PRO: PR:P35573