G6PC - Glucose-6-phosphatase - human protein (Function)
 
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G6PC »  Glucose-6-phosphatase   [ EC 3.1.3.9 ]  (G6Pase)
 
Protein also known as:  Glucose-6-phosphatase alpha (G6Pase-alpha).
Gene name:  G6PC
Family name: Glucose-6-phosphatase
Entry whose protein(s) existence is based on evidence at protein level
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1 67 2
GENE REF ISO

Function

 show evidences
Overview 
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.  
  • CuratedUniProtKB
GO molecular function 
Glucose-6-phosphatase activitydefinition[GO:0004346]  
3
  • IDAMGI
  • IDAUniProtKB
Phosphate ion bindingdefinition[GO:0042301]  
1
  • IMPUniProtKB
Phosphotransferase activity, alcohol group as acceptordefinition[GO:0016773] silver  
  • IEAOrtholog Compara
GO biological process 
Cholesterol homeostasisdefinition[GO:0042632] silver  
  • IEAOrtholog Compara
Dephosphorylationdefinition[GO:0016311]  
3
  • IDAGOC
Gluconeogenesisdefinition[GO:0006094]  
1
  • IMPUniProtKB
  • IEAUniPathway
Glucose 6-phosphate metabolic processdefinition[GO:0051156] silver  
  • IEAOrtholog Compara
Glucose homeostasisdefinition[GO:0042593]  
1
  • IMPUniProtKB
Glucose-6-phosphate transportdefinition[GO:0015760] silver  
  • IEAOrtholog Compara
Glycogen catabolic processdefinition[GO:0005980] silver  
  • IEAOrtholog Compara
Glycogen metabolic processdefinition[GO:0005977]  
1
  • TASPINC
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Regulation of gene expressiondefinition[GO:0010468] silver  
  • IEAOrtholog Compara
Steroid metabolic processdefinition[GO:0008202] silver  
  • IEAOrtholog Compara
Triglyceride metabolic processdefinition[GO:0006641] silver  
  • IEAOrtholog Compara
Urate metabolic processdefinition[GO:0046415] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.9: D-glucose 6-phosphate + H(2)O D-glucose + phosphate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+2538  
Carbohydrate digestion and absorption  hsa04973+2538  
Galactose metabolism  hsa00052+2538  
Glycolysis / Gluconeogenesis  hsa00010+2538  
Insulin signaling pathway  hsa04910+2538  
Metabolic pathways  hsa01100+2538  
Starch and sucrose metabolism  hsa00500+2538  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Metabolism  REACT_111217  
Transmembrane transport of small molecules  REACT_15518  
 
More information is available from:
 

Keywords

Biological process 
Gluconeogenesis  definition   [KW-0312]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P35575
Other
GeneWiki: G6PC
GenomeRNAi: 2538
PRO: PR:P35575