MYH9 - Myosin-9 - human protein (Function)
 
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MYH9 »  Myosin-9
 
Protein also known as:  Cellular myosin heavy chain, type A.
Gene name:  MYH9
Entry whose protein(s) existence is based on evidence at protein level
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1 302 2
GENE REF ISO

Function

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Overview 
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.  
1
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • IDAMGI
Contributes to actin filament bindingdefinition[GO:0051015]  
5
  • IDAUniProtKB
  • IDAMGI
Contributes to actin-dependent ATPase activitydefinition[GO:0030898]  
3
  • IDAUniProtKB
  • IDAMGI
ADP bindingdefinition[GO:0043531]  
1
  • IDAMGI
ATP bindingdefinition[GO:0005524]  
2
  • IDAMGI
ATPase activitydefinition[GO:0016887]  
1
  • IDAUniProtKB
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Microfilament motor activitydefinition[GO:0000146]  
2
  • IDAMGI
  • IDAUniProtKB
Motor activitydefinition[GO:0003774]  
1
  • NASUniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • IDAUniProtKB
Protein anchordefinition[GO:0043495]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
13
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDAUniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • IMPUniProtKB
Actin filament-based movementdefinition[GO:0030048]  
2
  • IDAMGI
  • IDAUniProtKB
Actomyosin structure organizationdefinition[GO:0031032]  
1
  • IDAUniProtKB
Angiogenesisdefinition[GO:0001525]  
1
  • IDAUniProtKB
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAUniProtKB
Blood vessel endothelial cell migrationdefinition[GO:0043534]  
1
  • IMPUniProtKB
Cytokinesisdefinition[GO:0000910]  
1
  • IMPUniProtKB
Establishment of meiotic spindle localizationdefinition[GO:0051295] silver  
  • IEAOrtholog Compara
Establishment of T cell polaritydefinition[GO:0001768] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • NASUniProtKB
Leukocyte migrationdefinition[GO:0050900]  
1
  • NASUniProtKB
Meiotic spindle organizationdefinition[GO:0000212] silver  
  • IEAOrtholog Compara
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • IDAUniProtKB
Monocyte differentiationdefinition[GO:0030224]  
1
  • IEPUniProtKB
Myoblast fusiondefinition[GO:0007520] silver  
  • IEAOrtholog Compara
Platelet formationdefinition[GO:0030220]  
1
  • IMPUniProtKB
Protein transportdefinition[GO:0015031]  
1
  • IMPUniProtKB
Regulation of cell shapedefinition[GO:0008360]  
1
  • IMPUniProtKB
Single organismal cell-cell adhesiondefinition[GO:0016337] silver  
  • IEAOrtholog Compara
Termination of G-protein coupled receptor signaling pathwaydefinition[GO:0038032] silver  
  • IEAInterPro 2 GO
Uropod organizationdefinition[GO:0032796] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Regulation of actin cytoskeleton  hsa04810+4627  
Salmonella infection  hsa05132+4627  
Tight junction  hsa04530+4627  
Viral myocarditis  hsa05416+4627  
According to Reactome, this protein belongs to the following pathways:
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Sema4D induced cell migration and growth-cone collapse  REACT_19277  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Cell shape  definition   [KW-0133]
Molecular function 
Motor protein  definition   [KW-0505]
Myosin  definition   [KW-0518]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYH9
GenomeRNAi: 4627
PRO: PR:P35579