MYH9 - Myosin-9 - human protein (Function)
 
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Protein
Gene
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MYH9 »  Myosin-9
 
Protein also known as:  Cellular myosin heavy chain, type A.
Gene name:  MYH9
Entry whose protein(s) existence is based on evidence at protein level
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1 274 2
GENE REF ISO

Function

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Overview 
Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.  
2
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • MGI
Contributes to actin filament bindingdefinition[GO:0051015]  
5
  • UniProtKB
  • MGI
Contributes to actin-dependent ATPase activitydefinition[GO:0030898]  
3
  • UniProtKB
  • MGI
ADP bindingdefinition[GO:0043531]  
1
  • MGI
ATP bindingdefinition[GO:0005524]  
2
  • MGI
ATPase activitydefinition[GO:0016887]  
1
  • UniProtKB
Calmodulin bindingdefinition[GO:0005516]  
1
  • UniProtKB KW
Microfilament motor activitydefinition[GO:0000146]  
2
  • MGI
  • UniProtKB
Motor activitydefinition[GO:0003774]  
1
  • UniProtKB
Poly(A) RNA bindingdefinition[GO:0044822]  
1
  • UniProtKB
Protein anchordefinition[GO:0043495]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
14
  • IntAct
  • UniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
1
  • UniProtKB
Actin filament-based movementdefinition[GO:0030048]  
2
  • MGI
  • UniProtKB
Actomyosin structure organizationdefinition[GO:0031032]  
1
  • UniProtKB
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB
Blood vessel endothelial cell migrationdefinition[GO:0043534]  
1
  • UniProtKB
Cytokinesisdefinition[GO:0000910]  
1
  • UniProtKB
Establishment of meiotic spindle localizationdefinition[GO:0051295] silver  
1
  • Ortholog Compara
Establishment of T cell polaritydefinition[GO:0001768] silver  
1
  • Ortholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • UniProtKB
Leukocyte migrationdefinition[GO:0050900]  
1
  • UniProtKB
Meiotic spindle organizationdefinition[GO:0000212] silver  
1
  • Ortholog Compara
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
1
  • UniProtKB
Monocyte differentiationdefinition[GO:0030224]  
1
  • UniProtKB
Myoblast fusiondefinition[GO:0007520] silver  
1
  • Ortholog Compara
Negative regulation of actin filament severingdefinition[GO:1903919]  
2
  • UniProtKB
  • Ortholog Curator
Phagocytosis, engulfmentdefinition[GO:0006911]  
1
  • Ortholog Curator
Platelet aggregationdefinition[GO:0070527]  
1
  • UniProtKB
Platelet formationdefinition[GO:0030220]  
1
  • UniProtKB
Positive regulation of protein processing in phagocytic vesicledefinition[GO:1903923]  
1
  • Ortholog Curator
Protein transportdefinition[GO:0015031]  
1
  • UniProtKB
Regulation of cell shapedefinition[GO:0008360]  
1
  • UniProtKB
Uropod organizationdefinition[GO:0032796] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Regulation of actin cytoskeleton  hsa04810+4627  
Salmonella infection  hsa05132+4627  
Tight junction  hsa04530+4627  
Viral myocarditis  hsa05416+4627  
According to Reactome, this protein belongs to the following pathways:
EPHA-mediated growth cone collapse  R-HSA-3928663  
Regulation of actin dynamics for phagocytic cup formation  R-HSA-2029482  
RHO GTPases activate CIT  R-HSA-5625900  
RHO GTPases activate PAKs  R-HSA-5627123  
RHO GTPases activate PKNs  R-HSA-5625740  
RHO GTPases Activate ROCKs  R-HSA-5627117  
Sema4D induced cell migration and growth-cone collapse  R-HSA-416572  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Cell shape  definition   [KW-0133]
Molecular function 
Motor protein  definition   [KW-0505]
Myosin  definition   [KW-0518]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MYH9
GenomeRNAi: 4627
PRO: PR:P35579