ACTN2 - Alpha-actinin-2 - human protein (Function)
 
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ACTN2 »  Alpha-actinin-2
 
Protein also known as:  Alpha-actinin skeletal muscle isoform 2.
Gene name:  ACTN2
Family name: Alpha-actinin
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.  
  • CuratedUniProtKB
GO molecular function 
Actin filament bindingdefinition[GO:0051015] silver  
  • IEAOrtholog Compara
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Cytoskeletal protein bindingdefinition[GO:0008092]  
2
  • IDAUniProtKB
FATZ bindingdefinition[GO:0051373]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
2
  • IPIIntAct
Integrin bindingdefinition[GO:0005178]  
1
  • TASUniProtKB
Ion channel bindingdefinition[GO:0044325]  
3
  • IPIBHF-UCL
LIM domain bindingdefinition[GO:0030274] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
17
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
  • IPIBHF-UCL
Protein dimerization activitydefinition[GO:0046983]  
1
  • IDAUniProtKB
Structural constituent of muscledefinition[GO:0008307]  
1
  • TASPINC
Thyroid hormone receptor coactivator activitydefinition[GO:0030375] silver  
  • IEAOrtholog Compara
Titin bindingdefinition[GO:0031432]  
2
  • IPIBHF-UCL
Titin Z domain bindingdefinition[GO:0070080]  
1
  • IPIBHF-UCL
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • TASUniProtKB
Focal adhesion assemblydefinition[GO:0048041]  
1
  • IMPUniProtKB
Microspike assemblydefinition[GO:0030035]  
1
  • IDAUniProtKB
Negative regulation of potassium ion transmembrane transporter activitydefinition[GO:1901017]  
1
  • IMPBHF-UCL
Negative regulation of potassium ion transportdefinition[GO:0043267]  
1
  • IMPBHF-UCL
Negative regulation of protein localization to cell surfacedefinition[GO:2000009]  
1
  • IMPBHF-UCL
Positive regulation of potassium ion transmembrane transporter activitydefinition[GO:1901018]  
1
  • IDABHF-UCL
Positive regulation of potassium ion transportdefinition[GO:0043268]  
1
  • IDABHF-UCL
Positive regulation of receptor activitydefinition[GO:2000273]  
  • IEAOrtholog Compara
Protein homotetramerizationdefinition[GO:0051289]  
1
  • IDAUniProtKB
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • NASUniProtKB
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IMPBHF-UCL
Regulation of RNA biosynthetic processdefinition[GO:2001141]  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+88  
Amoebiasis  hsa05146+88  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+88  
Focal adhesion  hsa04510+88  
Leukocyte transendothelial migration  hsa04670+88  
Regulation of actin cytoskeleton  hsa04810+88  
Systemic lupus erythematosus  hsa05322+88  
Tight junction  hsa04530+88  
According to Reactome, this protein belongs to the following pathways:
CREB phosphorylation through the activation of CaMKII  REACT_20642  
Nephrin interactions  REACT_23832  
Ras activation uopn Ca2+ infux through NMDA receptor  REACT_20546  
Striated Muscle Contraction  REACT_16969  
Unblocking of NMDA receptor, glutamate binding and activation  REACT_20594  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Actinin,_alpha_2
GenomeRNAi: 88
PRO: PR:P35609