BSG - Basigin - human protein (Function)
 
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Protein
Gene
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BSG »  Basigin
 
Protein also known as:  Tumor cell-derived collagenase stimulatory factor (TCSF); CD antigen CD147.
Gene name:  BSG
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 345 4
GENE REF ISO

Function

 show evidences
Overview 
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.  
2
  • UniProtKB
According to TCDB this is a transporter from family:
the basigin (basigin) family  8.A.23.1.1  
GO molecular function 
Mannose bindingdefinition[GO:0005537]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Decidualizationdefinition[GO:0046697] silver  
1
  • Ortholog Compara
Embryo implantationdefinition[GO:0007566] silver  
1
  • Ortholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
1
  • Ortholog Compara
Protein targeting to plasma membranedefinition[GO:0072661]  
1
  • Ortholog Curator
Response to cAMPdefinition[GO:0051591] silver  
1
  • Ortholog Compara
Response to mercury iondefinition[GO:0046689] silver  
1
  • Ortholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Basigin interactions  REACT_12560  
Degradation of the extracellular matrix  REACT_118572  
Integrin cell surface interactions  REACT_13552  
Pyruvate metabolism  REACT_2071  
 

Keywords

Molecular function 
Blood group antigen  definition   [KW-0095]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Basigin
GenomeRNAi: 682
PRO: PR:P35613