BSG - Basigin - human protein (Function)
 
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Protein
Gene
References

 
BSG »  Basigin
 
Protein also known as:  Tumor cell-derived collagenase stimulatory factor (TCSF); CD antigen CD147.
Gene name:  BSG
Entry whose protein(s) existence is based on evidence at protein level
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1 311 4
GENE REF ISO

Function

 show evidences
Overview 
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the basigin (basigin) family  8.A.23.1.1  
GO molecular function 
Mannose bindingdefinition[GO:0005537]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Decidualizationdefinition[GO:0046697] silver  
  • IEAOrtholog Compara
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Protein targeting to plasma membranedefinition[GO:0072661]  
  • ISSOrtholog Curator
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to mercury iondefinition[GO:0046689] silver  
  • IEAOrtholog Compara
Response to peptide hormonedefinition[GO:0043434] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Extracellular matrix organization  REACT_118779  
Hemostasis  REACT_604  
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Blood group antigen  definition   [KW-0095]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Basigin
GenomeRNAi: 682
PRO: PR:P35613